Page 44 - Proceeding of Plenary Abstract of Parallel Symposim

untuk stabilisasi BBB yang mengalami kerusakan sebagai akibat invasi kuman patogen
dan virus dan dapat memperkuat struktur BBB untuk mencegah invasi kuman patogen
maupun virus. Meskipun gagal napas merupakan manifestasi utama COVID-19 yang
berat, keterlibatan ginjal pada infeksi COVID-19 juga umum dijumpai. Cedera tubular
akut sering terjadi, meskipun sering ringan, namun fungsi ginjal berkurang secara nyata.
Penelitian pada hewan coba membuktikan pengaruh probiotik LIS-10506 signifikan pada
regenerasi tubulus ginjal yang mengalami pyelonefritis. Temuan ini juga dapat digunakan
sebagai rasionalisasi pemakaian probiotik dalam upaya mencegah dan meringankan efek
COVID-19 terhadap gangguan fungsi ginjal.

Daftar pustaka

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COVID-19. Nat Commun 12, 3534 (2021). https://doi.org/10.1038/s41467-021-23886-3.
5. Ranuh Reza, Athiyyah AF, Darma A, Riawan W, Surono I, Marto Sudarmo. The expression
of nuclear factor E2-related factor 2 (Nrf2) and nitrotyrosine (3-NT) : The protective effect
of Lactobacillus plantarum IS 10506 on pancreatic ß-cell damage in diabetic rat model. Pre-
liminary study. 2020.
6. Boldrini M, Canoll PD, Klein RS. How COVID-19 Affects the Brain. JAMA Psychia-
try. 2021;78:682–3. doi:10.1001/jamapsychiatry.2021.0500.
7. Ranuh Reza, Athiyyah AF, Darma A, dkk. Probiotic Lactobacillus plantarum IS-10506 on
glial fibrillary acidic protein (GFAP) of astrocyte expression and platelet endothelial cell ad-
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Kongres Nasional Ilmu Kesehatan Anak XVIII 29