Page 75 - Abstract Book KONIKA 18

Hemato-Oncology

O-HO-007
Correlation of D-Dimer and Length of Stay in Pediatric Patient
with Malignancy Infected by COVID 19

Yulia Evita Sari Sembiring, Ariawan, Bambang Sudarmanto
Department of Pediatrics, Faculty of Medicine Universitas Diponegoro/Dr. Kariadi General Hospital,
Semarang, Central Java, Indonesia

Abstract
Background Prevalence of COVID-19 has been increasing worldwide. Early stage of Covid 19 infection in
malignancy is associated with high D-dimer, indicating activation of coagulation pathways and thrombosis.
This condition leads to prolonged length of stay (LOS). Objective To analyze D-Dimer level and LOS in
pediatric patient with malignancy infected by COVID 19. Methods A cohort retrospective study was performed
in Kariadi General Hospital from March 2020 to July 2021. The subject were all patients with malignancy
aged 3-208 months who infected by COVID-19. Prolonged LOS is defined as ≥ 14 days. Analysis was done
with Pearson correlation coefficient and Anova. Results Thirty patients infected COVID 19 with underlying
malignancy were identified. We found that underlying diseases were 36.7% with acute lymphoid leukemia,
14% with lymphoma, and 10% with solid tumour. According to level of severity, 36.7% patients were classified
into critically ill, 30% with severe symptoms and 33.3% were moderate symptoms. Pearson analysis showed
that D dimer level has positive linear correlation with LOS in pediatric patients with malignancy infected
by COVID 19 (r=0.379, P=0.039). Anova analysis showed that D-Dimer level was significantly higher in
critically ill patients than severe or moderate symptoms (6525 vs. 4712 vs. 1826, P=0.036) and critically ill
patients had significantly longer LOS (P=0.000). Conclusion D-dimer level was significantly correlated with
longer LOS in pediatric patients with malignancy infected by COVID 19 especially in critically ill patients.
Keywords: D dimer; COVID 19; length of stay; critically ill

KONIKA XVIII Abstract Book 29