Page 78 - Abstract Book KONIKA 18

Infection & Tropical Diseases

O-ITD-005
Free Radical (Malondialdehyde) as A Shock Biomarker
in Dengue Hemorrhagic Fever

Ira Megasari, Husein Albar, Dasril Daud
Department of Child Health, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia

Abstract
Background Although there have been many advances in management of DHF, the morbidity and
mortality rates are still high. Until now, there is no biomarker that can predict the occurance of DHF/DSS.
Objective To compare the levels of malondialdehyde in DHF and DSS and assess MDA levels that can be
used as biomarkers of shock. Methods This cross-sectional study was conducted in Makassar, from April
2019 to February 2020. Serum malondialdehyde was collected in 73 patients with clinical diagnosis of DHF
and DSS (age range: 1 month to 18 years) who met the inclusion and exclusion criteria. Data was analyzed
using SPSS. Results 73 patients were enrolled, consisting of 56 DHF and 17 DSS. There were no significant
differences based on gender, nutritional status, and age between the groups. The average MDA levels in
both groups were increased whether the higher level of MDA was found in DSS group with P=0.003. The
cutt-off point of MDA level < 2.18 nmol / ml has a diagnostic value to show that shock not yet occur with
negative predictive value 86.4%, OR 0.258 95%CI 0.08 to 08. Conclusion In this study, MDA values
< 2.18 nmol/mL may be used as biomarker that shock has not occured in DHF.
Keywords: malondialdehyd;, dengue hemorrhagic fever; biomarker; shock

O-ITD-006
The Prevalence of Viral Hepatitis after Multiple Transfusions
in Children with Thalassemia at Dr. Mohammad Hoesin Hospital Palembang

Enggrajati Silitonga, Yulia Iriani, Ariesti Kamila
Department of Child Health, Faculty of Medicine, Universitas Sriwijaya/Mohammad Hoesin General Hospital,
Palembang, South Sumatera, Indonesia
Abstract
Background Transfusion-dependent conditions such as thalassemia are at risk of viral hepatitis B (VHB)
and C (VHC) infection. The prevalence of post-transfusion viral hepatitis was influenced by vaccination
coverage and health facilities. Objective To determine the prevalence and risk factors of VHC and VHB in
thalassemia patients at Dr Mohammad Hoesin Hospital (RSMH). Methods It was a cross-sectional study.
Data were obtained from pediatric inpatient and outpatient medical records at RSMH from June 2018 to
June 2021. Hepatitis C virus (HCV) infection was screened by anti-HCV test and confirmed by PCR RNA
HCV. Risk factors were analyzed with X2 test. Results There were 184 thalassemia patients; 57.8% were
boys, and the median age was 8 (range 1-17) years old. The HCV seroprevalence was 36/184 (19.5%),
80.5% with positive HCV RNA. The interval between diagnosis of VHC and thalassemia was 77.67 (range
5-134) months. 30/36 (83,5%) seropositive subjects were asymptomatic. Viral hepatitis B occurred in 8/184
(4.9%). The interval between diagnosis of VHB and thalassemia was 77.12 (range 56-96) months. Eight
VHB patients also HCV seropositive. Patients suffered from post-transfusion viral hepatitis showed a higher
number of multiple transfusions (OR 3.427; 95%CI 0.77 to 15.19; P=0.087). Conclusion The total prevalence
of viral hepatitis with multiple blood transfusions is 19.5 %. There is a significant association between viral
hepatitis with multiple transfusions.
Keywords: viral hepatitis; multiple transfusion; thalassemia

32 KONIKA XVIII Abstract Book