Page 72 - Abstract Book KONIKA 18

Hemato-Oncology

O-HO-001
Comparison of Serum Glutamic Oxaloacetic Transaminase and Serum Glutamic
Pyruvic Transaminase (SGPT) Before and After Induction and Consolidation
Phase Chemotherapy in Children with Standard Risk of
Acute Lymphoblastic Leukemia

Tengku Benyamin, Bidasari Lubis, Supriatmo
Department of Child Health, Faculty of Medicine Universitas Sumatera Utara/H. Adam Malik General Hospital,
Medan, North Sumatera, Indonesia
Abstract
Background Acute leukemia is a hematopoietic progenitor cell disorder characterized by the
presence of 20% or more blast cells. Liver toxicity occurs by infiltration of leukemic cells and by
administration of chemotherapeutic agents which is described by an increase in SGOT and SGPT levels.
Objective To determine the effect before and after the induction and consolidation phase of chemotherapy on
increasing levels of SGOT and SGPT in children with standard risk of ALL. Methods A cohort prospective
study was conducted among children with ALL aged 18 years at the RSUP. H. Adam Malik Medan from
January 2019-April 2021. Assessment of liver toxicity by examination of SGOT and SGPT levels before and
after chemotherapy. To assess the difference between two variables with the Wilcoxon test and the Friedman
test followed by Post-Hoc test with Wilcoxon. Results A total of 54 children were analyzed. The mean levels
of SGOT and SGPT before and after chemotherapy had a significant correlation (P = 0.001) in induction phase
but they had no correlation in consolidation phase (P=0.466 for SGOT, P=0.753 for SGPT). Measurements
of SGOT levels had two difference (P=0.001) and SGPT levels had four difference (P=0.001; P=0.048) in
induction phase but they had no difference in consolidation phase. Conclusion There is a difference in the
mean levels of SGOT and SGPT before and after completion of chemotherapy in the induction phase, not
in the consolidation phase. Measurements of SGOT and SGPT levels have differences during chemotherapy
in the induction phase, not in the consolidation phase.
Keywords: SGOT; SGPT; chemotherapy; acute lymphoblastic leukemia

O-HO-002
Clinical Characteristics and Outcomes of COVID-19 in Pediatric Cancer Patients
in Harapan Kita Women and Children Hospital

Fajar Subroto, Dina Garniasih, Nia Astarina, Akhil Deepak Vatvani
Department of Child Health, Hematology Oncology Division, PKIAN RSAB Harapan Kita, Jakarta, Indonesia
Abstract
Background COVID-19 infection in children with cancer has generated new challenges in pediatric oncology
worldwide, especially in resource limited countries. Is it important to maintain cancer treatment as a priority,
however some factors such as lack of hygiene culture, sociocultural behaviors characterized by close personal
relation would increase the risk of infection. Data regarding COVID-19 in pediatric cancer patients is still
limited. Objective To describe the clinical characteristics and outcome of Pediatric Cancer Patients in our
hospital. Methods This study took place from year July 2020 till July 2021. Clinical characteristics and
outcome of the cancer patients undergoing chemotherapy with COVID-19 were recorded. Analysis was done
using descriptive statistics with SPSS version 21. Results A total of 19 patients had COVID-19 infection.
Most patients were male (57.9%). The most common type of cancer was acute lymphoblastic leukemia
(73.7%) undergoing chemotherapy. Mean age of the patients were 6.6 (SD 3.1) years. Most patients had mild
symptoms (57.9%). Three patients (15.8%) had severe symptoms. The most common symptom was cough
(73.7%), followed by fever (63.2%), runny nose (63.2%), myalgia (36.8%), nausea and vomiting (26.3%)
and anosmia (26.3%). 1 patient was admitted to the ICU. Two (10.5%) did not recover from the infection.
Death occurred in 4 patients (21.1%), out of which 2 occurred 1 month after recovery. Conclusion Most
patients had mild symptoms. Extra attention should be given to these group of patients to avoid being infected.
Keywords: cancer; COVID-19; clinical characteristics; outcome

26 KONIKA XVIII Abstract Book