Page 70 - Abstract Book KONIKA 18

Gastroenterohepatology

O-GEH-003
Effectiveness of Probiotic on Eradication Helicobacter pylori Gastritis in Children

Masitah Nasution , Supriatmo , Aridamuriany D. Lubis , Gontar A. Siregar , Chairul Yoel , Rizky Adriansyah 1
1
1
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Department of Child Health and Department of Internal Medicine , Medical Faculty, Universitas Sumatera Utara,
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1
Medan, North Sumatera, Indonesia
Abstract
Background Helicobacter pylori is one of causing intestinal and gastric ulcers and one of the factors that can
cause gastric malignancy. The prevalence of H. pylori infection is more than 80% in developing countries.
Probiotics have beneficial effects on health if administered in an adequate amount. The most commonly
used as probiotics are Lactobacillus and Bifidobacteria. H.pylori colonization is interfered with by regular
ingestion of L. acidophilus, and the value of urea breath test (UBT) decreased approximately 10% after four
weeks of treatment. Objective To assess the effectiveness of probiotic in eradication of H. pylori gastritis in
children along with triple therapy. Methods This clinical trial design in children with H. pylori gastritis in a
network hospital in Medan. Sampling was carried out from August 2019 until April 2020 with randomization
techniques and double-blind in children suffering from H. pylori gastritis. Statistical assessment was carried
out by Mc Nemar test. Results There was no significant difference between probiotics and triple therapy with
only triple therapy, but there was a significant difference in reducing the side effects of nausea/vomiting and
diarrhea in the probiotic group (P=0.015). Conclusion Probiotic supplementation can reduce the adverse
effects experienced during eradication therapy.
Keywords: children; Helicobacter pylori; triple therapy; gastritis; probiotics

24 KONIKA XVIII Abstract Book