Page 76 - Abstract Book KONIKA 18

Infection & Tropical Diseases

O-ITD-001
HsCRP as Predictor of Mortality in Pediatric Patients Infected with Covid19

Gerin Orviyanti, Ariawan, Bambang Sudarmanto
Department of Child Health, Faculty of Medicine, Universitas Diponegoro/Dr. Kariadi General Hospital,
Semarang, Central Java, Indonesia
Abstract
Background Coronavirus disease 2019 (Covid-19) mortality rate have been increasing worldwide. Indonesian
Pediatrician Society (IPS) stated that 12.6% of patients infected with Covid19 were children. Study in one of
tertiary referral hospital in Indonesia showed 40% children with Covid19 had fatal outcome. Data regarding
the predictors of mortality in patients with Covid-19 especially in children remains limited. Objective To
determine the prognostic factor of high sensitivity C-reactive protein (HsCRP) level in pediatric patients
infected with Covid-19 for predicting mortality outcomes. Methods In this retrospective cohort study, we
included pediatric patients with confirmed Covid-19 at Kariadi Hospital from March 2020 - June 2021 who
were checked for HsCRP level at admission day. Mann Whitney test was used in the analysis, followed
by ROC curve and Chi Square analysis. Results Among 83 pediatric patients with Covid19, 42 patients
were checked for HsCRP level. Three postoperative patients were excluded. From 39 patients analyzed, 9
patients died during hospitalization with higher HsCRP level compared to survivors (9.34 vs. 3.40, P = 0.03).
Optimal cut off point of HsCRP level was 4.61 mg/dL. HsCRP >4.61 mg/dL was significantly associated
with mortality (RR 3.63; CI 1.21 to 10.90). Conclusion HsCRP level was useful in predicting mortality in
pediatric patients with Covid19.
Keywords: high sensitivity C-reactive protein; HsCRP; covid19; pediatric patients; predictor of
mortality

O-ITD-002
The Effect of vitamin D Levels on COVID-19 on Pediatric Population:
A Meta-analysis and Systematic Review

Andrew Jonatan
Lapangan Indrapura Hospital, Surabaya, East Java, Indonesia

Abstract
Background Due to the COVID-19 pandemic, lack of outdoor activities increases the risk of vitamin D
deficiency in children. Vitamin D is thought to have beneficial effects on COVID-19 patients. However,
there are still very few studies studying the effects of vitamin D on paediatric. Objective To evaluate the
association between serum vitamin D levels and clinical outcomes among COVID-19 paediatric population.
Methods We reviewed PubMed and Google Scholar for articles studying the association between vitamin
D on COVID-19 paediatric patients, with limitations on English published articles only. Statistical analysis
was conducted under PRISMA-MOOSE guideline and quality checklist and was computed using RevMan
5.4. Results Ten studies consist of 1,225 patients were reviewed. Low vitamin D levels was significantly
associated with higher incidence of severe COVID-19 with pooled OR 5.57 (1.59-19.55; P=0.007). Clinical
symptoms were compared between low and normal vitamin D levels. Incidence of fever, cough, ageusia,
anosmia, headache, and fatigue were not significantly different with pooled RR 2.13 (0.13-33.73; P=0.59),
1.25 (0.25-6.22; P=0.78), 0.47 (0.05-4.76; P=0.52). 1.25 (0.21-7.41; P=0.81), 0.91 (0.33-2.55; P=0.86),
1.02 (0.47-2.22; P=0.96), respectively. The average levels of leukocytes and lymphocytes in the two groups
were also not significantly different with pooled RR -0.49 (-1.39-0.41; P=0.28), -0.73 (-1.65-0.20; P=0.12),
respectively. Conclusion Low serum vitamin D levels (<20 ng/mL) significantly associated with the severity
of COVID-19 on paediatric patients but do not affect symptoms and laboratory parameters. Vitamin D
supplementation might be beneficial for children who undergo home confinement.
Keywords: vitamin D; COVID-19; children

30 KONIKA XVIII Abstract Book