Page 65 - Abstract Book KONIKA 18

Endocrinology

O-ENDO-001
Quality of Life in Down Syndrome Children with Hypothyroidism
during Pandemic of Covid-19

Adkhiatul Muslihatin, Muhammad Faizi, Nur Rochmah, and Irwanto
Department of Child Health, Faculty of Medicine, Universitas Airlangga /Dr. Soetomo General Academic Hospital,
Surabaya, East Java, Indonesia

Abstract
Background Down syndrome (DS) children with hypothyroidism are at risk to suffered from psychological
disturbance especially during Covid 19 pandemic. Therefore quality of life is very important to be evaluated.
Objective To evaluate Quality of life of DS children with hypothyroidism during pandemic of Covid-19.
Methods A cross-sectional study was conducted in 30 DS children with hypothyroidism, aged 2-18 years, in
Pediatric Endocrine outpatient clinic dr. Soetomo Hospital, during April-July 2021. The Peds QoL Generic
core was used in this study. It consists of physical (p), emotional(e), social(s), and school(sc) functioning
dimension. Spearman, Mann-Whitney, and Independent-sample-t test to analyze the dimension in Peds
QoL Generic core. Results 30 DS children with hypothyroidism included in the study. Mean scores for all
dimension was 58.3, whereas mean score for each dimension: p;e;s;sc was (54,1;63.8;56.6;61,6) ,respectively.
There was significant difference between boy and girl on p functioning dimension with median score was
(57.8,45.9) whereas there was not difference on e, s, and sc functioning dimensions. There was correlation
between age and e functioning dimension (P=0.02;r=-0.4). Participants aged 2-4 years had the poorest mean
scores than older aged (57.2). Conclusion DS children with hypothyroidism had poor quality of life during
pandemic Covid-19. The p functioning was the poorest. An intervention is needed to improve quality of life.
Keywords: Down syndrome; hypothyroidism; children; quality of life

O-ENDO-002
The Relationship between Duration of Administration of Antiepileptic Drugs
with Vitamin D Levels in Children with Epilepsy
in Saiful Anwar Hospital Malang, Indonesia

Chintami Putry Rejekiya, Harjoedi Adji Tjahjono, Nugroho Danu Tri Subroto, Irfan Agus Salim
Universitas Brawijaya/Saiful Anwar General Hospital, Malang, East Java, Indonesia

Abstract
Background Epilepsy is a common neurological disorder in children of all ages with a prevalence ranging
from 4-8 per 1000 population. Antiepileptic drugs have been particularly implicated for osteoporosis risk given
their effects on vitamin D. Objective We examined the relationship between duration of administration of
antiepileptic drugs with vitamin D levels in children with epilepsy. Methods This study uses an observational
analytic design with a cross-sectional approach and the sampling method is consecutive sampling. Sixty-
one epilepsy patients who met the inclusion criteria were collected from the pediatric neurology outpatient
clinic of RSUD. Dr. Saiful Anwar Malang in August 2020 - February 2021. Furthermore, samples were
grouped based on duration of therapy, use of antiepileptic drugs into groups of therapy duration of 6 months
- 1 year and> 1 year. Blood samples were taken from peripheral veins and measured in serum vitamin D
levels by the ELISA method. We use statistical analysis of correlation test with the Spearman Correlation
test. Results Vitamin D levels were obtained on sixty-one patients with epilepsy. The results showed that
female characteristics compared to male were 1.26: 1 with a mean age of 4.69 years. Based on the t test, we
obtained significance value 0,015, concluded that there are significant differences in vitamin D levels in the
therapy group for 6 months - 1 year and> 1 year. Conclusion Vitamin D levels were significantly related to
the duration of administration of antiepileptic drugs (sig< 0.05).
Keywords: duration of administration antiepileptic drugs Vitamin D; pilepsy; vitamin D profiles

KONIKA XVIII Abstract Book 19