Page 338 - Abstract Book KONIKA 18

Neurology

P-NEU-003
The Neuromodulator Effect of Vagal Nerve Stimulation
as the Treatment of Medically Refractory Epilepsy in Comparison
with Surgical Approach: A Systematic Review

1
Muhammad Al Anas , Dwi Herawati Ritonga 2
1
Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Medan ,
2
Department of Child Health, Deli Serdang Hospital, Lubuk Pakam , North Sumatera, Indonesia
Abstract
Background Restorative options in medically refractory epilepsy are restricted to ablative brain surgery, the
trial of antiepileptic medications, or palliative procedures. Vagal nerve stimulation (VNS) is an accessible
palliative method of which the mechanism of action isn't well understood, yet with set up adequacy for
medically refractory epilepsy and low occurrence of incidental effects. Objectives To evaluate the action of
epilepsy treatment options. Methods We conduct the searches to find the relevant studies published in 2016-
2021 with PRISMA charts. For English published statistical studies, we include all studies conducted on
pediatric epileptic patients who have undergone epilepsy surgery and VNS. Results Anti-epileptic impacts
of VNS incorporate expanded movement of the locus coeruleus (LC) neurons with a raised norepinephrine
(NE) discharge in the hippocampus, cortex, and amygdala. VNS-modulatory consequences for other synapse
frameworks such as cholinergic, GABAergic, and glutamatergic that depend on the activation of the LC-
NE pathway. While in pediatric epilepsy, early surgical intervention is becoming frequently recommended
to work on cognitive and behavioral outcomes with unequivocally portray the epileptogenic zone.
Conclusion The general rate of complication caused by epilepsy surgery was sensibly low (5%), suggesting
that epilepsy medical procedures particularly especially temporal lobe resection can be safe preferably
with recent procedure options, while VNS could be more effective as therapy begins at early stages pre- or
post-seizure onset to decide the preventative role of VNS in human epileptogenesis when the treatment is
given promptly.
Keywords: refractory epilepsy; epilepsy surgery; vagal nerve stimulation

P-NEU-004
History of Febrile Seizure in Children with Epilepsy
Angelica, Nurhayati Masloman, Praevilia M. Salendu
Department of Child Health, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R. D. Kandou Hospital,
Manado, North Sulawesi, Indonesia
Abstract
Background Febrile seizure is the most common convulsive event of childhood, occurring in 2% to 5%
in infants and children, usually appears between 6 months and 6 years of age. Epilepsy is defined as the
occurarence of two episodes or more of unprovoked, afebrile seizures in more than 24 hours apart. With
the increasing recognition of epilepsy, many investigators have attempted to identify factors that relate
to developing epilepsy. Many studies show that febrile seizure increases risk of developing epilepsy.
Objective To describe the prevalance of history febrile seizure in children diagnosed with epilepsy.
Methods A descriptive cross-sectional study of children age 6 months -18 years old diagnosed with epilepsy
in Prof. Dr. R. D. Kandou Hospital from January 2017- December 2020. We collected data of history
febrile seizure from medical record and classified to simple febrile seizure, complex febrile seizure and
status epilepticus. Results There were 134 patients included, consisted of 69 males (51.5%) and 65 females
(48.5%). We found 30 (22.4%) of patients had history of febrile seizue before. Among of the patients, 19
(63.3%) patients had complex febrile seizure, 9 (30%) patients had simple febrile seizure, and 2 (6.7%)
patients had status epilepticus. Conclusion More than one-fifth children with epilepsy had history of febrile
seizure. Majority of them had complex febrile seizure.
Keywords: epilepsy; febrile seizure

290 KONIKA XVIII Abstract Book