Page 343 - Abstract Book KONIKA 18

Neurology

P-NEU-013
Risk Factors of Cerebral Palsy in Children

Hans Natanael, Nurhayati Masloman, Praevilia M. Salendu
Department of Child Health, Prof. Dr. R. D. Kandou Hospital, Faculty of Medicine Universitas Sam Ratulangi,
Manado, North Sulawesi, Indonesia
Abstract
Background Cerebral Palsy (CP) is the most common motor disability in childhood. It is a group of permanent
disorders of movement and posture causing activity limitations, attributed to non-progressive disturbances
in the brain occurring early in development. The prevalence and risk factors of CP in children vary among
studies in Indonesia. Objective To look for the prenatal, perinatal, and postnatal history and risk factors of
CP in children. Methods This study is an retrospective study using medical record data of patients in Child
Health Department Prof. Dr. R. D. Kandou Hospital Manado, taken between January 2018 – June 2021. 52
respondents from mothers with CP children aged 0-18 years whom met the inclusion criteria were included in
this study. Diagnosis of CP was made according to Levine (POSTER) criteria. Risk factors and causes were
identified with the provision of questionnaires. Data analysis was primarily based on descriptive statistics.
Results Total of 52 subjects were enrolled, consisted of 29 boys and 23 girls. Data were grouped into prenatal,
perinatal, postnatal history and risk factors. Prenatal factors were 10.34%, perinatal 16.34%, and postnatal
34.61%. Conclusion Postnatal factors contributed the most to the risk factors of cerebral palsy in children.
Keywords: cerebral palsy; prenatal; perinatal; postnatal

P-NEU-014
Profiles of CNS Leukemia in Children at Estella Pediatric Cancer Centre,
Prof. Dr. R. D. Kandou Hospital Manado
Indah Megawati, Nurhayati Masloman, Praevilia M. Salendu, Stefanus Gunawan, Max F. J. Mantik
Department of Child Health, Faculty of Medicine Universitas Sam Ratulangi/Prof. Dr. R. D. Kandou Hospital,
Manado, North Sulawesi, Indonesia
Abstract
Background CNS leukemia is the infiltration of leukemic cells into the central nervous system that causes
neurological disorders in leukemia patients which the incidence has been increasing in the past few years.
Objective To review the profile of CNS leukemia in children such as clinical manifestations, laboratories, and
survival pattern. Methods This was a retrospective observational study at Estella Pediatric Cancer Centre,
Department of Child Health, Prof. R.D. Kandou Manado Hospital, from January 2011 to February 2021.
We included all leukemia patients, both ALL and AML. Results We review a total of 140 leukemia patients
medical records admitted from January 2011 to February 2021, with 65 patients (46%) CNS leukemia. It
was found majority in males than females (2:1) which more common in aged 3-10 years old (66%), 100%
in ALL patients, with the majority type of ALL were B Lineage 59 patients (91%) and divided to L1 47
patients (72%), L2 18 (28%), and none of L3. The clinical manifestations most commonly found were
headache 44%, seizures 20%, vomiting 23%, decreased of consciousness 10%, and paralysis 4%. From
laboratories, the leucocyte > 50.000 were found in 30 patients (46%) and CSF were dominant cloudy in 40
patients (61%). There were 24 patients (37%) were survived, with the survival rate up to 3 years was 10,7%
and relapse case were 9 patients where all died in one year of relapse treatment. Conclusion CNS leukemia
could worsen the survival rate of leukemia.
Keywords: CNS leukemia; leukemia; pediatric cancer

KONIKA XVIII Abstract Book 295