Page 337 - Abstract Book KONIKA 18

Neurology

P-NEU-001
Electrical Status Epilepticus during Slow-wave Sleep in a 2-year-old Boy

Nur’atmi Gusti Dewi , Yazid Dimyati, Cynthea P. Destariani
Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara/RSUP Haji Adam Malik,
Medan, North Sumatera, Indonesia
Abstract
Background Electrical status epilepticus during slow wave sleep (ESES) is a rare disease, self-limiting
disorder characterized by epilepsy with multiple seizure types, neuropsychological disturbances in the global
form or selective regression of cognitive function, motor disturbances, and electroencephalographic (EEG)
findings suggestive of typical of continuous epileptic activity that occurs during sleep. Although clinical
manifestations in children with ESES vary, the most severe clinical condition is a decrease in cognitive
function in addition to clinical seizures. Objective To report a case of electrical status epilepticus during slow
wave sleep (ESES) that is diagnosed by the results of the EEG examination Case A 2 years old boy, came to
Adam Malik Hospital with main complaint seizures without fever 1 day before admission to the hospital, the
frequency of seizures were 3 times per day, the duration of seizures were 2-3 minutes. He got tonik-klonik
seizure all over the body. The patient had a history of seizures without fever since 1 month ago. After seizure,
he looks weak and inactived. Decreased consciousness was found since 1 week ago, the patient only sleeps
continuously. He only wake up for 4 hours in a day. History of trauma was denied. From the results of the
EEG examination, it was found electrical status epilepticus during slow wave sleep (ESES) and disappeared
after the patient received corticosteroid therapy. Conclusion High-dose steroid therapy should be given as
soon as the diagnosis of ESES is established, followed by maintenance doses for several months to years.
Keywords: electrical status epilepticus during slow wave sleep; high-dose steroid therapy

P-NEU-002
The Association Between Family History of Epilepsy and Type of Seizure
in Children with Epilepsy

Lidya Lustoyo Putrajaya, Praevilia Margareth Salendu, Nurhayati Masloman
Department of Child Health, Faculty of Medicine Universitas Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital,
Manad, North Sulawesi, Indonesia
Abstract
Background Genetic factors account for many cases of epilepsy. Familial occurrence of epilepsy ranges
from 5 to 32% in different studies. Some of the risk factors for sudden death in epilepsy (SUDEP) include
high seizure frequency (specifically tonic-clonic type which is a generalized seizure), younger age, mental
retardation, and polytherapy. Objective To investigate the association between family history of epilepsy and
type of seizure in children with epilepsy. Methods Sample was taken from pediatric patients with epilepsy who
were admitted to Prof. Dr. R. D. Kandou General Hospital, Manado from January 2017 until December 2020.
Data were collected from medical record. Data were analyzed on IBM SPSS Statistics 25.0 package program.
Results From 134 patients which consist of 68 (50.8%) males and 66 (49.2%) females, we documented
the family history of epilepsy of every patient and also the type of seizure the patient’s had. There were 50
(37.3%) patients with positive family history of epilepsy. Forty (80%) of them had generalized seizure and
the remaining 10 (20%) patients had focal seizure. Besides, the 84 (62.7%) patients who didn’t have any
family history of epilepsy, 52 (61.9%) patients had generalized seizure and the remaining 32 (38.1%) patients
had focal seizure. Positive family history of epilepsy increased the risk of developing generalized seizure by
2.462 fold (P = 0.029, 95% confidence interval, 1.083 to 5.595). Conclusion In this study positive family
history of epilepsy was associated with the type of seizure in children with epilepsy.
Keywords: family history, type of seizure; epilepsy

KONIKA XVIII Abstract Book 289