Page 336 - Abstract Book KONIKA 18

Nephrology

P-NEP-035
Risk Factors for Body Mass Index Changes
in Children With Idiopathic Nephrotic Syndrome

Suputra Timmy, Rompies Ronald, Umboh Adrian
Department of Child Health, Faculty of Medicine, Universitas Sam Ratulangi, Manado, North Sulawesi, Indonesia

Abstract
Background In children with nephrotic syndrome there is an increased risk of energy and protein malnutrition.
Children with nephrotic syndrome are prone to both macro and micronutrient deficiency and are at risk
of impaired growth, muscle mass depletion and cognitive impairment. Aim of the study was to evaluate
the risk factors that influence the change of Body Mass in children with Idiopathic Nephrotic Syndrome
(INS) during initial 6 month therapy with prednisone. Objective To assess the nutritional status of children
with nephrotic syndrome attending the Children Ward of Prof. Dr. R. D. Kandou Manado. Methods Case
control study during October 2018-April 2019. Children with diagnosis of idiopathic nephrotic syndrome
were included, controls are patients who are treated in an inpatient room. We studied 42 children with INS
(33♂,9♀,12.67±3.6 years) treated during 6 months with prednisone due to initial INS and 42 control healthy
children (24♂, 18♀, 11.19±3.3 years). Following risk factors were evaluated such as age, gender, and body
mass index. Results Mean initial BMI Z-score was -0.831 ± 1.32 in children with INS and 0.14 ±1.4 in the
control group, after 6 months administration of prednisone therapy, the mean BMI was 0.30 ±1.14 (P=0.001)
and 0.07 ± 1.5 (P=0.209) in the control group. Increasing BMI Z-Score after 6 month therapy of steroid
correlated with initial BMI Z-Score (P=0.001). Conclusion Initial prednisone therapy for 6 month may result
in body mass index increase in children with INS. Risk factors for body mass increase in children with INS
during the first 6 months of therapy include low initial BMI.
Keywords: children; nephrotic syndrome; prednisone; nutritional status; risk factors

P-NEP-036
Effect of Lipid Levels on The Occurrence of Relapse Nephrotic Syndrome

Suputra Timmy, Umboh Valentine, Umboh Adrian
Department of Child Health, Faculty of Medicine. Universitas Sam Ratulangi, Manado, North Sulawesi, Indonesia

Abstract
Background Frequent relapse nephrotic syndrome is defined as steroid sensitive nephrotic syndrome with
2 or more relapses within 6 months, or 4 or more relapses within a 12 months period. Relapse rate after
corticosteroid discontinuation is 39-59%. Hyperlipidemia occurs in primary nephrotic syndrome. Proteinuria
is the main pathophysiological change that can affect serum colloid osmotic pressure which causes the
synthesis of serum proteins such as lipoproteins in the liver to be transported to serum so that the severity of
proteinuria is related to lipid abnormalities that occur. Objective To find effect of lipid level on the occurrence
of relapse nephrotic syndrome. Methods Thirty three children with nephrotic syndrome were included in this
cohort study form January 2017 until January 2020 at Kandou Hospital, Manado. Blood specimens were
collected to determine plasma lipids. Plasma lipids were examined in the acute and remission phases. Follow
up was carried out six months after remission to determine the occurrence of relapsing nephrotic syndrome
Results Of 33 nephrotic syndrome patients, 9 had relapsed. There were highly significant differences in
total cholesterol and triglyceride between acute nephrotic syndrome and nephrotic syndrome in remission.
Remission triglyceride level was a risk factor in relapsing nephrotic syndrome with the prevalence risk of
6.25. Conclusion High lipid levels in remission phase is associated with an increased risk in children with
relapses of nephrotic syndrome.
Keywords: children; relapses; nephrotic syndrome; hyperlipidemi; proteinuria

288 KONIKA XVIII Abstract Book