Page 334 - Abstract Book KONIKA 18

Nephrology

P-NEP-031
Association between Hyperuricemia with Lipid Profiles and Acute Kidney Injury
in Nephrotic Syndrome

Natharina Yolanda, Valentine Umboh, Adrian Umboh
Department of Child Health, Faculty of Medicine Universitas Sam Ratulangi/
Prof. R. D. Kandou General Hospital, Manado, North Sulawesi, Indonesia

Abstract
Background Hyperuricemia is a common finding in nephrotic syndrome and associated with renal disease
progression. Recognition the effect of hyperuricemia could justify early treatment and prevent further renal
damage. Objective To analyse the association between hyperuricemia with lipid profile and acute kidney
injury (AKI) in nephrotic syndrome. Methods A cross-sectional study was carried out in children with
nephrotic syndrome treated at Paediatric Nephrology Outpatient Clinic, Prof. R. D. Kandou General Hospital
Manado in January-December 2020. Children with nephrotic syndrome was divided into hyperuricemia
and non-hyperuricemia group. Comparison of total cholesterol, triglyceride, albumin, urea, and creatinine
mean level between two groups was tested with independent T-test. Comparison of AKI and hypertension
incidence between two groups was tested with Chi square. Results There were 58 children recruited in this
study (28 children in hyperuricemia group and 30 children in non-hyperuricemia group). The mean level
of serum cholesterol, triglyceride, and albumin in hyperuricemia group was no different compared to those
without hyperuricemia: total cholesterol 405 vs 439 mg/dL, P=0.127; serum triglyceride 273 vs. 278 mg/dL,
P=0.842; albumin 1.7 vs. 1.7 g/dL, P=0.751. The mean level of urea and creatinine was significantly higher
in hyperuricemia group compared to non-hyperuricemia group: urea 54 vs. 30 mg/dL; creatinine 1.7 vs. 0.7
mg/dL. There was significantly higher incidence of AKI in hyperuricemia group (OR 18.7; 95%CI 2.2 to
158.3; P=0.001). Hypertension incidence was not different between two groups. Conclusion Hyperuricemia
in children with nephrotic syndrome is correlated with higher level of serum urea, creatinine, and incidence
of AKI.
Keywords: acute kidney injury; cholesterol; hyperuricemia; nephrotic syndrome

P-NEP-032
Correlation of Hematologic Parameters with Serum Albumin
in Children with Nephrotic Syndrome

Anita Yolaningtyas, Valentine Umboh, Adrian Umboh
Department of Child Health, Faculty of Medicine Universitas Sam Ratulangi/
Prof. dr. R. D. Kandou Hospital, Manado, North Sulawesi, Indonesia
Background Nephrotic Syndrome (NS) is characterized by hidden onset of edema accompanied by proteinuria,
hypoalbuminemia and hypercholesterolemia. Regarding the examination of hematologic parameters in
patients with NS, one can recognize the risk of infection, and thromboembolism. Objective To identify the
correlation of hematologic parameters with serum albumin in children with NS. Methods A cross-sectional
study was applied to children with NS between 1-18 years old and were taken by medical record at Child
Health Department, Prof. dr. R. D. Kandou, Manado. Analysis was carried out using Pearson correlation and
linear regression test. Results Fifty-eight children (41 boys and 17 girls) were included in this study, and the
mean age 11.43 years. There were 3 types of hematologic parameters that correlates with serum albumin
levels; it was hemoglobin (P<0.05; r=-0.288), hematocrit (P<0.05; r=-0.315), ESR (P<0.0001; r = 0.493).
The regression analysis result showed a linier correlation between serum albumin (x) and hemoglobin (y),
with the equation: ỳ = 14.521 –1.071x, between serum albumin (x) and hematocrit (y), with the equation:
ỳ = 44.278–3.633x, between serum albumin (x) and ESR (y), with the equation: ỳ=17.797+ 2.51x. Pearson
correlation between leucocyte, thrombocyte and serum albumin showed no significance, with P value
> 0.05. Conclusion There was a correlation between hemoglobin, hematocrit and ESR rate with albumin.
There were means with examination of hematologic parameters, we could recognize the risk of infection,
and thromboembolism in patient with NS.
Keywords: nephrotic syndrome; hematologic parameters; hypoalbuminemia

286 KONIKA XVIII Abstract Book