Page 97 - Abstract Book KONIKA 18

Respirology

O-RES-003
Comparison of Diagnostic Accuracy between SARS-CoV-2 Ag-RDT
and rRT-PCR Test in Children at Dr. Mohammad Hoesin Hospital Palembang

Herdanti Dwi Putri, Fifi Sofiah, Azwar Aruf, Kgs. Yangtjik
Departement of Child Health, Faculty of Medicine Universitas SriwijayaDr. Mohammad Hoesin General Hospital,
Palembang, South Sumatera, Indonesia

Abstract
Background Real-time reverse transcription-polymerase chain reaction (rRT-PCR) is the reference laboratory
method to diagnose SARS-CoV-2 infection, which is costly and timely. Therefore we need another diagnostic
test that is cheaper and faster such as the antigen rapid detection test (Ag-RDT), which has different positive
predictive value (PPV) and negative predictive value (NPV) depend on the prevalence of the population.
Objective To evaluate the PPV and NPV of Ag-RDT compare to SARS-CoV-2 rRT-PCR in the pediatric
patient at Dr. Mohammad Hoesin Hospital Palembang. Methods Medical records of children suspected
of SARS-CoV-2 infection from April to July 2021 were reviewed for the result of Ag-RDT and rRT-PCR.
Results There were 40 children suspected of SARS-CoV-2 infection with median age 7 years (range 1
month-17 years), 24 boys and 16 girls. Symptoms of the patient with both positive results of Ag-RDT and
rRT-PCR were asymptomatic (8/15), fever (4/15), cough (2/15), diarrhea (2/15), shortness of breath (1/15)
and cold (1/15). Fifteen of 25 patients with positive rRT-PCR results also had positive Ag-RDT, while 15
patients had negative Ag-RDT and rRT-PCR results, given the sensitivity of 60% and specificity of 100%
with PPV 100% and NPV 60%. Conclusion Considers the values of specificity and PPV, a positive result
of Ag-RDT can be used to rule in SARS-CoV-2 infection in the pediatric patient at Dr. Mohammad Hoesin
Hospital, while negative result gives a possibility of 40% false negative.
Keywords: SARS-CoV-2 infection; children; Ag-RDT; rRT-PCR

O-RES-004
Does COVID-19 Pandemic Affect Characteristics and Habits of Asthmatic
Children? A Comparison Study Before and During Pandemic

Madeleine Ramdhani Jasin, Gufron Nugroho, Valerie Sunhaji, Darmawan Budi Setyanto
Department of Child Health, Faculty of Medicine, Universitas Indonesia/Dr.Cipto Mangunkusumo Hospital, Jakarta,
Indonesia

Abstract
Background Study of COVID-19 impact to asthmatic children yield various results, as some suggesting
increased exacerbation and lifestyle changes. Objective To compare characteristics and habits of asthmatic
children before and during pandemic. Methods A cross-sectional study was performed in August 2021. Data
was collected from questionnaire distributed online. Data were analyzed using McNemar test for paired data,
or Chi-square for association between categorical data. Results Sixty asthmatic children participated in this
study. Most were male (66.7%), age 5-10 years old (55%). Mild persistent asthma was the most common
classification (30%), followed by intermittent asthma (21.7%). However, most subjects (65%) only took
reliever therapy, and merely 16.8% took controller. Most children lived in free of smoke household (56.7%)
and no pets at home (61.7%). Around 81% reported no increased acute asthma symptoms during pandemic.
Compared to before pandemic, there was no difference of frequency in asthma symptoms during pandemic.
Proportion of more frequent asthma symptoms during pandemic was higher in persistent asthma, compared
to intermittent asthma (23.3% vs. 7.7%, P=0.4). There was difference in more frequently cleaning AC before
and during pandemic (69.8% vs. 30.2%, P=0.039), though no difference in other hygiene habits. Children
who spent >10 hours in room were increased during pandemic (5% vs. 56.7%). Duration of staying inside
room was not significantly associated with more frequent asthma symptoms (P=0.875). No differences of
therapy compliance before and during pandemic. Conclusion Before and during pandemic, there are no
differences in asthma symptoms frequency, most of hygiene habits, and therapy compliance.
Keywords: asthma; children; pandemic; symptoms; habits

KONIKA XVIII Abstract Book 51