Page 92 - Abstract Book KONIKA 18

Nutrition & Metabolic Diseases

O–NMD–001
Relationship Between Vitamin D Deficiency with Level of Interleukin 6
in Obese Children

Apriani Aridan, Aidah Juliaty A. Baso
Department of Child Health, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia

Abstract
Background Obesity is a pathological condition with excessive or abnormal accumulation of body fat.
Obesity is associated with a chronic low-grade inflammatory condition with progressive infiltration of
immune cells in adipose tissue. Vitamin D deficiency is a systemic inflammatory response associated with the
activation of a number of body defense mechanisms, including the proinflammatory cytokine interleukin-6.
Objective To analyze the relationship between vitamin D deficiency and interleukin-6 levels in obese children.
Methods This research is a cross sectional study. Obese child patients aged 11 to 17 years in private junior
high school and senior high school in Makassar City. The subjects of this study were divided into groups
with vitamin D deficiency and normal. Results There were 51 children with vitamin D deficiency and 45
children with normal vitamin D. No significant differences in sex and age were found between the vitamin
D deficiency and normal groups. The results of the interleukin-6 level test between the vitamin D deficiency
group and the normal group showed a significant difference P=0.001 (P<0.05). Interleukin-6 cut-off point
between the vitamin D deficiency and normal group, which is 39.30 pq/mL, has a sensitivity of 76.5%, a
specificity of 73.3% and an odds ratio (OR) of 8.938 with a 95%CI 3.545 to 22,533. Conclusion There is
a significant relationship between vitamin D deficiency and interleukin-6 levels in obese children. Vitamin
D deficiency is one of the parameters that can predict an increase in interleukin-6 levels in obese children.
Keywords: obese children; vitamin D deficiency; interleukin-6.

O–NMD-002
High Energy Nutrition in Infants Following Congenital Heart Surgery:
A Systematic Review and Meta-Analysis

Evan Matthew Putra, Valerie Michaela Wilhemina, Anthea Casey
Faculty of Medicine, Universitas Katolik Atma Jaya, Jakarta, Indonesia
Abstract
Background Postoperative nutrition support is an important aspect for pediatric patients’management
following congenital heart surgery. Recent studies suggested energy enriched nutrition may help achieve
nutrition targets earlier and reduce postoperative complications. Objective To review the effects of high energy
nutrition in infants following congenital heart surgery. Methods We search Wiley, SAGE, PubMed, EBSCO,
ProQuest and Cochrane databases for randomized and clinical trials comparing the effect of postoperative
high energy nutrition versus control on postoperative weight gain, length of hospital stay (LOS), infectious
complications and feeding intolerance in infants undergoing congenital heart surgery. Random effects model
was used to estimate the pooled risk ratio (RR) of treatment effects. Pooled mean difference (MD) was used
to compare weight gain and LOS. Heterogeneity was assessed using I2. The risk of bias was assessed using
the Cochrane Risk Of Bias tool. Results Of 152 articles, 8 trials were included for analysis (n=466). Weight
gain was significantly higher in the postoperative high energy nutrition group (MD +0.46 kg; 95%CI 0.16
to 0.76, I2=0%). Although statistically insignificant, trends for lower postoperative infectious complication
(RR 0.74, 95%CI 0.53 to 1.03; I2=0%) shorter LOS (MD -0.34 days, 95%CI -0.56 to 0.12; I2=91%) were
observed in the intervention group. Furthermore, a higher risk of feeding intolerance was observed in
intervention group RR 1.20 (95%CI 0.70 to 2.07; I2=30%). Conclusion Postoperative high energy nutrition
following congenital heart surgery improve weight gain, and may decrease infectious complications. It may
also decrease LOS but it should be interpreted cautiously given the high heterogeneity.

Keywords: congenital heart disease; nutrition; postoperative

46 KONIKA XVIII Abstract Book