Page 90 - Abstract Book KONIKA 18

Neurology

O-NEU-001
Responds of Conventional Titration of Antiepileptic Drug
n Epileptic Children with High Risk of Drug Resistance

Sitti Radhiah, Irawan Mangunatmadja
Department of Child Health, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital,
Jakarta, Indonesia

Abstract
Background Children with a high risk for drug resistant epilepsy (DRE) may not respond to the conventional
titration of antiepileptic drug (AED). Objective To describe the response to conventionally titrated AED in
children with a high risk for DRE. Methods A retrospective study was conducted between July and August
2021 reviewing medical records of children with risk factors for DRE at Cipto Mangunkusumo Hospital
Outpatient Clinic who had conventionally titrated AED. Risk factors for DRE included onset seizure, number
of seizures before treatment, abnormal electroencephalography (EEG), aetiology and status epilepticus.
Results A total 19 patients were included in this study with mean age of 126 month (10.5 year). Most patients
had not achieved seizure freedom (73.7%). The lenght of treatment was 8.11±4.37 years. The average patient
received 3 (range 2-4) drugs. The most commonly used drugs were valproic acid (78.9%) and topiramate
(73.7%). There was no difference in the proportion of risk factors between those who were free of seizures
and those who were not (P>0.05). The average number of risk factors were higher in those who still had
seizure (3.4 vs. 2.4), but the difference was not statistically significant (P=0.2). Conclusion The proportion
of seizure freedom in patients with risk factor for DRE who received conventionally titrated AED was very
low. The number of risk factors may increase the risk of failure to achieve a seizure remission. Rapid titration
of AED can be considered in this group of patient.
Keywords: conventional titration; antiepileptic drug; drug resistant epilepsy

O-NEU-002
The Effect of Risk Factors on the Degree of Sensorineural Hearing Loss
in Children in Adam Malik Hospital

Santa Ulina, Johannes H. Saing, Bugis M. Lubis
Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan,
North Sumatera, Indonesia

Abstract
Background The Hearing Loss Association of America (HLAA) estimates that 2 to 3 out of every
1000 children in the United States are born with the condition hearing loss detected in one or both ears.
Objective To determine the effect of risk factors on the degree of SNHL in children. Methods This is a
cross-sectional study from medical record data on all patients who underwent ABR examination at Haji
Adam Malik Hospital Medan from January 2018 to January 2021 by assessing the degree of SNHL and
prenatal, perinatal, and postnatal risk factors. Results On characteristics, we found 41 (53.2%) males and 36
(46.8%) females, and the mean age was 3.78 (SD 3.45). The results of cross tabulation obtained 61 people
with severe degrees, 8 people with moderate degrees, and 8 people with mild degrees. Prenatal risk factors
with TORCH infection, use of ototoxic drugs, family factors, prematurity, and low birth weight were found
to have no significant relationship with a P value > 0.05. There was also no significant association with
perinatal risk factors such as neonatal asphyxia and neonatal jaundice. Postnatal risk factors with postnatal
infection and seizures were also obtained with a P value > 0.05. Conclusion In every prenatal, perinatal,
and postnatal risk factor that has a risk factor for hearing loss even though the results are normal, the child
should be checked regularly every 6 months until the child reaches the age of 2 years.
Keywords: risk factors; sensorineural hearing loss; degree of hearing loss; BERA

44 KONIKA XVIII Abstract Book