Page 88 - Abstract Book KONIKA 18

Nephrology

O-NEP-005
Correlation of Hepcidin-Ferritin Ratio and Cardiovascular Disease
in Children with Chronic Kidney Disease

Retno Palupi-Baroto, Mulyadi M. Djer, Sudung O. Pardede
Department of Child Health, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital,
Jakarta

Abstract
Background Cardiovascular disease (CVD) is a common complication and an important cause of mortality
in children with chronic kidney disease (CKD). Hepcidin is a protein that regulates iron metabolism and has
been closely linked with the pathogenesis of anemia in chronic disease. Low hepcidin-ferritin ratio represents
the condition of iron overload intracellularly. The correlation of hepcidin-ferritin ratio and CVD has not been
studied in children with CKD. Objective To investigate the correlation of hepcidin-ferritin ratio and CVD in
children with chronic kidney disease. Methods This was a cross sectional study that involved children aged
2–18 years with CKD in Cipto Mangunkusumo Hospital. Echocardiography was performed to describe left
ventricle hypertrophy (LVH), systolic and diastolic function as well as increase cIMT. Plasma hepcidin was
obtained and analysed using ELISA (enzyme-linked immunosorbent assay). Results This study involved
78 patients with CKD stage 3-5. Median age was 13 (range 2-17) years. The study showed that there was a
significant correlation of hepcidin-ferritin ratio and LVH [adjusted OR 0.63 (95%CI 0.40 to 0.98); P=0.042)
in multivariate logistic regression. In children with anemia, the correlation of hepcidin-ferritin ratio and LVH
was stronger [adjusted OR 0.57 (95%CI 0.36 to 0.89); P=0.015]. There was no correlation of hepcidin-ferritin
ratio and systolic, diastolic dysfunction and cIMT. Conclusion Our study showed the correlation between
hepcidin-ferritin ratio and LVH, particularly in children with anemia. This study could not describe causal
relationships; therefore, further prospective cohort studies are needed to confirm our results.
Keywords: Hepcidin; cardiovascular disease; left ventricle hypertrophy; chronic kidney disease;
children

O-NEP-006
Sleep Disturbance in Children with Mild to Moderate and Severe Chronic
Kidney Disease in Haji Adam Malik Hospital Medan

Siti A Dalimunthe, Rosmayanti S Siregar, Ika C Dewi Tanjung
Department of Child Health, Faculty of Medicine Universitas Sumatera Utara/Adam Malik General Hospital,
Medan, North Sumatera, Indonesia

Abstract
Background Chronic kidney disease (CKD) is a problem that is quite often found in children. Generally,
children with CKD may experience physical and psychological problems, such as sleep disturbance.
Sleep disturbance in pediatric CKD are correlated with decrease quality of life. Objective To determine
the differences in sleep disturbance between mild-moderate and severe pediatric CKD. Methods Research
subjects were 30 patients with mild to moderate CKD and 30 patients with severe CKD at Haji Adam Malik
Hospital Medan from March to May 2021. Sampling was selected from consecutive sampling method. Direct
and indirect interviews were conducted on the parents of children with CKD. The Mann Whitney test was
performed to assess the significant difference in sleep disturbance scores between the severe and the mild to
moderate CKD group. Results About 41 patient experienced sleep disturbance, 29 patient were in the severe
CKD group. There was significant difference in sleep disturbance scores between severe and mild to moderate
CKD group. A significant relationship was found in variables of nutritional status, type of management,
parental education and classification of CKD on sleep disturbance in children. The most dominant variable
affecting sleep disturbance is the CKD classification. Conclusion There was significant difference between
the scores of sleep disturbances between severe and mild to moderate CKD group.
Keywords: sleep, disorder; pediatric; chronic kidney disease

42 KONIKA XVIII Abstract Book