Page 86 - Abstract Book KONIKA 18

Nephrology

O-NEP-001
Characteristic of Renal Involvements in Confirmed COVID-19 Pediatric Patients

Qashastia S. Paripurna, Krisni Subandiyah, Astrid K. Kardani
Department of Child Health, Faculty of Medicine Universitas Brawijaya, Saiful Anwar Hospital, Malang
Abstract
Background The novel coronavirus disease (COVID-19) caused systemic inflammation and multiple organ
involvement, including kidney injury. There was limited data reported renal involvement in COVID-19
pediatric patients. Objective To describe the characteristic of renal involvement in COVID-19 pediatric
patients in Saiful Anwar Hospital. Methods This cross-sectional study was conducted on pediatric patients
with COVID-19 infection in Saiful Anwar Hospital (June 2020 - July 2021). Diagnosis and the severity of
COVID-19 were established according to national guideline. The patients’ characteristics and laboratory
results were extracted from medical records. We evaluate glomerular filtration rate (GFR), proteinuria,
hematuria and blood pressure as renal involvement parameters. Comparison and correlation analysis were
conducted using SPSS version 23 program, with p<0.05 was statistically significant. Results There were 39
patients enrolled in this study (19 males and 20 females). 15 patients with mild symptoms of COVID-19, 11
and 13 patients with moderate and severe, respectively. We found 23/39 patients with hyperfiltration GFR
and 3/39 patient with Acute Kidney Injury. The mean of GFR were lower in severe COVID-19 compared
to mild or moderate COVID-19, but it was not statistically significant (P=0.263). Hematuria was found
in 2/39 patients and proteinuria were found in 2/39 patients. Hypertension was reported in 3/29 patients.
Hematuria, proteinuria and hypertension were also not correlate significantly with severity of COVID-19
(P>0.05). Conclusion The renal involvement was reported in pediatric COVID-19 patients, and GFR tends
to decreased in severe COVID-19 cases.
Keywords: COVID-19; pediatric, renal involvement; GFR; urinalysis; blood pressure

O-NEP-002
Relationship between Serum Hepcidin and Ferritin Levels
in Children with Chronic Kidney Disease

Hasriani, Jusli Aras, Syarifuddin Rauf
Department of Child Health, Faculty of Medicine Universitas Hasanuddin/
Dr. Wahidin Sudirohusodo General Hospital, Makassar, South Sulawesi, Indonesia
Abstract
Background Chronic kidney disease (CKD) is a health problem with increasing morbidity and mortality
over the last ten years. Objective To analyze the relationship between serum hepcidin and ferritin levels in
children with chronic kidney disease. Methods A cross sectional study in the pediatric division of Wahidin
Sudirohusodo Hospital from March to June 2021. It consisted of 40 children with CKD. Results The analysis
of the Spearman correlation test found a positive relationship between serum levels of hepcidin and ferritin
(r=0.417), P=0.007 (<0.05). The most common cause of CKD is nephrotic syndrome 19 (47.5%). Had ferritin
levels < 100 µg/L as many as 10 (25%) samples had ferritin levels > 100 µg/L and as many as 30 (75%). The
mean serum hepcidin level in ferritin < 100 µg/L was 25.46 ng/mL and the mean serum hepcidin level in
ferritin > 100 µg/L was 26.97 ng/mL. Serum hepcidin levels in CKD children are 15.8-36 ng/mL. Conclusion
There was no statistically significant difference between hepcidin levels and ferritin levels < 100 µg/L and
hepcidin levels against ferritin levels >100 µg/L. There is a positive relationship between serum hepcidin
levels and ferritin in children with CKD.
Keywords: Serum hepcidin levels; serum ferritin levels; pediatric chronic kidney disease

40 KONIKA XVIII Abstract Book