Page 63 - Abstract Book KONIKA 18

Emergency & Pediatric Intensive Care

O-EPIC-005
Correlation of Bacterial Infection Markers with Organ Dysfunction
Based on PELOD-2 Scores In Critically Ill Children

Mahadian Ismail Nasution, Aridamuriany Dwiputri Lubis, Beby Syofiani Hasibuan
Department of Child Health, Faculty of Medicine Universitas Sumatera Utara/Haji Adam Malik General Hospital,
Medan, North Sumatera, Indonesia

Abstract
Background Pediatric Logistic Organ Dysfunction 2 (PELOD-2) score is the score for organ dysfunction
that currently recommended in critically ill children. Laboratory markers that can describe the presence of
organ dysfunction in bacterial infections, such as neutrophils, lymphocytes, neutrophil/lymphocyte ratio
(NLR), platelet, red blood cell distribution width (RDW), C-Reactive Protein (CRP) and procalcitonin
(PCT). Objective To determine the relationship between neutrophil, lymphocyte, NLR, platelets, RDW, PCT,
and CRP with organ dysfunction based on PELOD-2 scores in critically ill children. Methods Analytical
analysis with cross sectional approach in critically ill patients age 1 month to 18 years treated at the High
Care Unit (HCU) and Pediatric Intensive Care Unit (PICU), Haji Adam Malik General Hospital, Medan,
from November 2020 – February 2021. Assessment of PELOD-2 scores as well as neutrophil, lymphocyte,
NLR, platelet, RDW, PCT, and CRP were conducted within 24 hours after patient was admitted. Results
A total of 52 subjects were analyzed. Neutrophil, lymphocyte, NLR, platelet and RDW values measured
in the first 24 hours had no correlation to PELOD-2 scores in critically ill children. PCT and CRP values
measured in the first 24 hours had a positive correlation to PELOD-2 scores in critically ill children
(r=0.463, P=0.001 for PCT and r=0.320, P=0.021 for CRP). Conclusion PCT and CRP values measured in
the first 24 hours were correlate with organ dysfunction based on PELOD-2 scores in critically ill children.
Keywords: bacterial infection markers; PELOD-2 scores; critically ill children

O-EPIC-006
Renal Angina Index as a Predictor of Acute Kidney Injury
in Critically Ill Children

Eva Astria, Valentine Umboh, Jose M. Mandei, Adrian Umboh
Department of Child Health, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou Hospital,
Manado, North Sulawesi, Indonesia

Abstract
Background Acute kidney injury (AKI) commonly occurs in critically ill children and is associated with
high rates of morbidity and mortality. Renal Angina Index (RAI) has recently been used as a tool to identify
patients at high risk for AKI, based on changes in kidney function – especially in critically ill children
Objective Using RAI to predict the incidence of AKI in critically ill children. Methods In this prospective
observational study, RAI was assessed on admission of critically ill children aged 1 month to 18 years, who
were admitted to the Pediatric Intensive Care Unit (PICU) at Prof. Dr. R.D. Kandou Hospital Manado from
January to September 2020. RAI was evaluated in identifying AKI on day 3 and day 7 and its association
to patients’ outcomes. Results 67 patients included in this study and renal angina (RAI≥8) was present in 32
of 67 patients (47.76%). Severe AKI was present in 23 of 67 patients (34.3%) on day 3 and 9 of 32 patients
(28.12%) on day 7. Patients with renal angina had a higher risk of developing any AKI (RR 5.35; 95%CI
1.8 to 15.7; P=0.002) and severe AKI (RR 7.71; 95%CI 2.3 to 25; P<0.0001). There was no significant
difference in mortality in patients with or without renal angina. RAI≥8 had an area under curve (AUC) of
0.75 (95%CI 0.63 to 0.87) in identifying patients with severe AKI on day 3. Conclusion RAI is a useful
indicator in predicting the occurrence of any AKI and severe AKI on day 3 and day 7 of treatment.
Keywords: renal angina index; acute kidney injury; children

KONIKA XVIII Abstract Book 17