Page 49 - Abstract Book KONIKA 18

Allergy Immunology

O-AI-005
Risk Factors of Lupus Nephritis

Aldila Vidya Ditha Arianti, Galuh Hardaningsih, Wistiani
Department of Child Health, Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, Indonesi
Abstract
Background Lupus nephritis (LN) is the most serious complication of systemic lupus erythematosus
(SLE). Lupus nephritis typically develops within the first 6 to 36 months. Known risk factors associated
with development of LN are younger age, elevated anti-dsDNA, hypertension and SLEDAI score.
Objective To analyse the risk factors for developing LN in children with SLE at Dr. Kariadi General Hospital.
Methods We analyzed the clinical manifestations and laboratory indexes of 29 children diagnosed with SLE
between January until June 2021. Nineteen patients with LN were compared to 10 SLE patients without LN.
Data were collected from complete medical record. A chi-square test for heterogeneity was performed. The
odds ratios (OR) are reported with 95% confidence interval with a level of 5% significance. The analysis
was performed using SPSS software. Results Hypertension was more frequently found in LN group than
in non-LN group (39% vs. 14 %; OR 5.6; 95%CI 1.0 to 30, P=0.036). Elevated anti ds-DNA was also more
frequently found in LN group than in non-LN group but not statistically significant (28% vs. 4%, OR 0.54;
95%CI 0.087 to 3.3, P=0.5), as were younger age (41% vs. 18%, OR 0.494, 95%CI 0.34 to 8.3, P=0.7) and
SLEDAI score (45% vs. 31%, OR 0.24; 95%CI 0.035 to 2.4, P=0.19). Conclusion Hypertension is a risk
factor for developing lupus nephritis in children with SLE.
Keywords: systemic lupus erythematosus; lupus nephritis; risk factors; hypertension

O-AI-006
Classification Criteria of ACR 1997, SLICC 2012, and EULAR/ACR 2019 in
Pediatric Systemic Lupus Erytematosus in Dr. Soetomo Hospital Surabaya

Azaria Amelia Adam, Ratih Kumala Sari, Diah Budiarti, Zahrah Hikmah,
Azwin Mengindra Putera Lubis, Anang Endaryanto
Department of Child Health. Faculty of Medicine Universitas Airlangga/Dr. Soetomo General Academic Hospital,
Surabaya, East Java, Indonesia

Abstract
Background The American College of Rheumatology (ACR) 1997, Systemic Lupus International
Collaborating Clinics (SLICC) 2012, and European League against Rheumatism (EULAR)/ACR 2019
SLE classification criteria are used to diagnose childhood-onset of Systemic lupus erythematosus (SLE).
Objective To compare the performances of the classification criteria of ACR 1997, SLICC 2012, and
EULAR/ACR 2019 among pediatric patients with SLE. Methods This descriptive retrospective study was
conducted at Pediatric Allergy and Immunology outpatient clinic of Dr. Soetomo Hospital, Surabaya between
years 2014 and 2019. All patient diagnosed with SLE were enrolled in the study. Results SLE was found
predominantly in females (78%). The median age at onset was 9 (range 2-17) years. The clinical manifestation
in different organs were as follows: hematological abnormalities in 54 patients (79.4%), musculoskeletal
involvement in 45 patients (66.1%), and skin involvement in 38 patients (55.8%). All patients were positive
anti-dsDNA. Positive ANA-test was in 41 (65%) patients. Sixty-two (68,4%) patients were diagnosed as SLE
by ACR 1997 criteria. This result was the same as SLICC 2012 criteria. However, by EULAR/ACR 2021
criteria, only 41 (65%) patients were diagnosed as SLE, while the other 22 (35%) patients were negative.
Conclusion Classification criteria of ACR 1997 and SLICC 2012 was similar. EULAR/ACR 2019 was
very different. Some patients were excluded as SLE by EULAR/ACR 2019 criteria because of the negative
result of ANA test.
Keywords: pediatric; systemic lupus erythematosus; ACR 1997; SLICC 2012; EULAR/ACR 2019

KONIKA XVIII Abstract Book 3