Page 47 - Abstract Book KONIKA 18

Allergy Immunology

O-AI-001
Economic Burden on Parents of Children with Systemic Lupus Erythematosus
at Mohammad Hoesin Hospital Palembang

Rizki Nandasari Sulbahri, RA Myrna Alia, Edy Novery, Yusmala Helmy
Department of Child Health, Faculty of Medicine Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital,
Palembang, South Sumatera, Indonesia

Abstract
Background Long-term management of SLE, including medication, regular visits, and laboratory
examination, may impact the family's economy. The economic burden is considered as a factor that may
influence the adherence and sustainability to treatment. Objective To assess the direct and indirect economic
burden on parents of the pediatric patient with SLE. Methods We conducted a survey using questionnaires
filled by parents or caregivers of the pediatric patient with SLE at Mohammad Hoesin Hospital Palembang
from May-June 2021. Direct economy burden included expenses on transportation and accommodation,
while indirect burden was measured by losing productive working time. Results There were 25 participants
in this study. The mean duration of disease was 2.26 (range 0.4-9) years. The mean length of stay of patients
was 10.9 (range 3-67) days each year. The mean direct cost during hospitalization was IDR 1,150,000 (IDR
300,000-5,000,000) per month and outpatient IDR 359,120 (IDR 60,000-1,500,000 per month. The cost of
drugs that were not covered by insurance was IDR 248,200 (IDR 50,000-600,000), the mean parent’s income
IDR 2,796,000 (IDR 500,000-6,000,000) per month. The mean total expenditure for outpatient was 13%,
while inpatients had 41% of income per month. Losing working time for parents was 36.8 days/year. The
average travel time to the hospital was 4.9 (range 0.25-12.25) hours. Conclusion The economic burden,
either directly or indirectly, on pediatric patients with SLE are quite significant and deserve a critical concern.
Keywords: economic burden; systemic lupus erythematosus; pediatric

O-AI-002
Correlation of Platelet-to-Lymphocyte Ratio, Neutrophil-to-Lymphocyte Ratio,
and C-Reactive Protein as Inflammation Parameters in Pediatric Systemic Lupus
Erythematosus with Coronavirus Infection (COVID-19)

Bunga Nirwani, Reni Ghrahani, Gartika Sapartini, Budi Setiabudiawan
Department of Child Health, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital,
Bandung, West Java, Indonesia

Abstract
Background Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, can invade all age
groups, including children. Pediatrics systemic lupus erythematosus (pSLE) patient, especially during
immunosuppressive therapy, is a vulnerable group to the coronavirus infection. Measuring the inflammation
process is essential to evaluate the disease progression and the treatment response. C-reactive protein is a
classic inflammation parameter used globally. The platelet-to-lymphocyte ratio (PLR) and the neutrophil-
to-lymphocyte ratio (NLR) are the basic inflammation parameters proposed, to evaluate the inflammation
process in a COVID-19 infection. Objective This study aims to evaluate the correlation of PLR and NLR
with CRP in pSLE patient with COVID-19 infection. Methods This is a cross-sectional study, using a primary
data. The data collection period was between March 2020 to August 2021 in Hasan Sadikin General Hospital.
Total 11 subjects recruited and the CRP, PLR, and NLR level of all recruited subjects was measured. The
data was then analyzed using descriptive analysis method. Results Eleven patients were diagnosed as pSLE
with COVID-19 during the study period. All patients were female (100%). There is weak evidence that the
PLR level have positive correlation with the CRP level (R -0.205, P=0.627). The NLR is also show a weak
evidence of an inversel corelation with -the subject CRP’s level (R -0.166; P=0.694). Conclusion PLR tend
to increase as the CRP level grow higher. In the other hand, NLR tend to decrease along with the lowering
of CRP level. Further studies are needed to determine the significance of this finding.
Keywords: systemic lupus erythematosus; COVID-19; pediatric

KONIKA XVIII Abstract Book 1