Page 298 - Abstract Book KONIKA 18

Neonatology

P-NEO-023
The Burden of Enteropathy and Risk Factors in Premature Infant

Putri MT Marsubrin, Maya Yulindhini, Rinawati Rohsiswatmo, Agus Firmansyah†
Department of Child and Health, Faculty of Medicine Universitas Indonesia/
Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Abstract
Background Enteropathy is a condition associated with increased intestinal permeability, malabsorption, and
systemic inflammation. Enteropathy has thought to increase the risk of sepsis. Sepsis is a condition that is
still a problem in the management of premature infant. Objective To examine the incidence and risk factors
of enteropathy in premature infant. Methods A prospective cohort study conducted in the Neonatal Unit,
Cipto Mangunkusumo Hospital (November 2019-January 2021) in infants with gestational age < 32 weeks or
birth weight < 1500 grams. Enteropathy was determined using Alpha-1 antitrypsin (AAT) examination with
the ELISA method. Stool samples were collected from 7-day-old infants and measured by DNA extraction.
Results A total of 43 infants have participated in this study. The mean gestational age (29.56 ± 2.675) and the
mean birth weight (1138.20 ± 262.70 g). As much as 53,4% of infants had enteropathy. Gestational age and
birth weight were associated with the incidence of enteropathy (P < 0.05). There was no difference between
the method of delivery, the use of antibiotics for the mother and infant, and the condition of the mother's
infection. This study also found an association between enteropathy and sepsis (P=0.02; RR=1.84 (1.02–3.31)).
Conclusion Gestational age and birth weight are factors that naturally affect enteropathy. Enteropathy is
associated with the incidence of sepsis and is a matter of concern for the management of premature infants.
Keywords: enteropathy; premature; AAT; sepsis

P-NEO-024
One Year Experienced of Neonatal SARS-CoV2 Infection at Ulin General
Hospital Banjarmasin: Rate of Vertical Transmission and Immunity Aspect

Nataniel Hadi Putra, Pricilia Gunawan H, Edi Hartoyo, Pudji Andayani, Ari Yunanto
Department of Child Health, Faculty of Medicine, Universitas Lambung Mangkurat/Ulin General Hospital,
Banjarmasin, South Borneo, Indonesia

Abstract
Background Covid-19 in neonates is an infection from the SARS-CoV2 in newborns up to 28 days of
age. Transmission of SARS-CoV2 through the placenta is believed to exist. There is no apparent data
regarding the rate of Covid-19 infection in neonates, especially in Indonesia. Objective To describe the rate
of Covid-19 infection in neonates from maternal confirmed cases in Ulin Tertiary Hospital, Banjarmasin.
Methods We conducted a cross-sectional study using secondary data from the medical records at Ulin
General Hospital from April 2020 – April 2021. Results There were 95 (24.5%) confirmed Covid-19 maternal
cases from total 388 suspected cases, 249 negative cases (64.1%), 44 (11,3%) cases were not tested for
nasopharyngeal swab. We found 11 confirmed neonatal cases from the first and second-day nasopharyngeal
swab, 68 neonates (71.58%) were tested negative, 16 neonates (16.84%) untested. Nine cases (82%) were
discharged with good condition, 2 cases (18%) were died. We conducted an examination for quantitative
SARS-CoV2 antibody in 10 confirmed neonates, at days 3-1 month after infection, we found all negative
with titer < 0.4 U/mL. Conclusion Transplacental transmission rarely occurred in maternal confirmed cases.
However, we found there is about 11% vertical transmission in our center. Vertical transmission of SARS-
CoV2 infection in neonates did not produce the future immunity for the baby. However, further research is
needed regarding the immunity aspect of Covid-19 infection in neonates.

Keywords: neonatal Covid-19; vertical-transmission; immunity

250 KONIKA XVIII Abstract Book