Page 296 - Abstract Book KONIKA 18

Neonatology

P-NEO-019
Characteristics, IT Ratio, CRP, and Outcomes of Neonates Clinically Diagnosed
with Sepsis versus Control at A Tertiary Hospital In Banjarmasin

Julia Kasab , Pudji Andayani , Pricilia Gunawan H. , Ari Yunanto 2
1
2
2
1
Faculty of Medicine and Child Health Department, Faculty of Medicine , Universitas Lambung Mangkurat,
2
Banjarmasin, South Borneo, Indonesia
Abstract
Background Neonatal sepsis is one of the leading causes of neonatal death with high morbidity, especially
in countries with poor access to adequately equipped and staffed healthcare facilities. Objective To analyze
the characteristics, immature/total neutrophil (IT ratio), C-reactive protein (CRP), and outcomes of clinically
diagnosed neonatal sepsis versus control at a tertiary hospital in Banjarmasin, Ulin General Hospital.
Methods This is an observational study using secondary data from the registry of neonates born at Ulin General
Hospital Banjarmasin, January-June 2021. The subjects were enrolled purposively with the following criteria:
have complete data included the results of IT ratio or CRP laboratory examination. Results The total subjects
included in this study were 147, divided into clinically diagnosed sepsis (44.2%) and control (55.8%). The
characteristics of subjects clinically diagnosed sepsis were predominantly male (58.5%, P>0.05), low birth
weight (41.5%, P<0.05), preterm (47.7%, P<0.05), appropriate for gestational age (67.7%), born without
asphyxia (44.6%) and by caesarian section (60%, P>0.05). IT ratio in the sepsis group was significantly
higher than the control group (0.11±0.01 vs. 0.06±0.005, P<0.00), while the CRP value was not significantly
different between sepsis and control group (7.4±2.1vs. 3.9±1, P=0. 42). The average length of hospitalization
was longer within the sepsis group (sepsis 12.72±0.85 vs. 4.65±0.26), and the number of death case between
two groups were not significantly different. Conclusion In the sepsis group, preterm and low birth weight
babies were more common to be found, with a significantly higher IT ratio and longer hospitalizations.
Keywords: neonatal sepsis; IT Ratio; CRP; outcomes.

P-NEO-020
Early Blood Gas Analysis in Preterm Infants and Brain Injury

Lucia Nauli Simbolon, Johannes Edy Siswanto
Department of Child Health, Harapan Kita Women and Children Hospital, Jakarta, Indonesia
Abstract
Background Brain damage and dysfunctions in preterm infants have been attributed to abnormal carbon
dioxide (PCO2), oxygen (PO2), and acidemia (pH) levels with adverse inpatient outcomes in preterm
babies. Recent resuscitation practice changes may influence these associations. Objective To assess the
range of the initial of PCO2, PO2, and pH in very low birth weight infants and their correlation to brain
injury outcomes. Methods A retrospective cohort study was conducted from April 2020 to March 2021 of all
preterm babies weighed <1500 gram born in Harapan Kita Mother and Child Hospital, with arterial blood gas
analysis performed within the first hour after birth and head ultrasonography within the first three days old.
Results Ninety four infants with mean (SD) birth weight 1142 gram, 44 infants newborns (46,8%) had normal
sonography and fifty other (53,2%) had abnormalities. Nineteen (20,2%) one of the infants had hypocarbia
(<30 mmHg), 70 (74,5%) had normocarbia (30-55 mmHg), and 5 (5,3%) had hypercarbia (>55mmHg). While
six infants (6.4%) had hypoxia (<50 mmHg), 63 (67%) normoxia, and 25 (26,6%) had hyperoxia. Twenty-
two infants (23.4%) had acidemia (<7.25), 59 (62,8%) normal (7.25-7.4) and 13 (13.8%) had alkalosis.
Multivariate logistic regression analysis showed no association of low or high PCO , PO , or pH with brain
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injury. Conclusion Early blood gas analysis could not be used as a predictor in the occurrence of brain injury.
Keywords: blood gas; preterm; infants; brain injury

248 KONIKA XVIII Abstract Book