Page 293 - Abstract Book KONIKA 18

Neonatology

P-NEO-014
Severe Thrombocytopenia in Neonate with Vertical Dengue Infection:
A Case Report

Endah Setyaningsih, Vandra Davin, Annisa Rahmania Yulman, Cynthia Centauri, Fahreza Aditya Neldi,
Putri Maharani Tristanita Marsubrin, Nina Dwi Putri
Universitas Indonesia Hospital, Depok, West Java, Indonesia

Abstract
Background Indonesia is one of hyperendemic dengue country. Dengue can infect wide range of population
age, including neonates. To date, few cases of vertical dengue infection have been published in the literature.
Objective To report a case of vertical dengue infection in a newborn. Case A mother with dengue infection
delivered a rigorous full-term newborn by C-section on the second day of dengue illness. The baby then
developed fever, petechial and rash over body on the fourth day of life. She was screened for neonatal
dengue and admitted to the neonatal ward. The complete blood count (CBC) revealed haemoglobin 14 g/
dL, haematocrit 45 vol%, leucocyte 13.000 /µL, platelet 87,000 /µL, positive for NS1 antigen. The chest
x-ray showed thickening of left pleural wall. She underwent serial examination of CBC and anti-dengue
IgG and IgM were positive on day 9. At presentation, we also did the sepsis work up to exclude differential
diagnosis. During follow up, the lowest platelet 8000 /µL was detected on the fifth day of illness and then
improved on the following day until 93,000 /µL at the end of hospitalization without transfusion. She also
developed minimal petechial and dengue rash and improving at discharged. She was adequately hydrated
with maintenance hydration and had close clinical and laboratory monitoring. The condition improved and
baby was discharged on the sixth day after admission. Conclusion Early recognition, appropriate treatment,
and close monitoring for the baby who delivered from mother with Dengue infection will significantly lead
to good outcome.
Keywords: dengue virus; neonatal dengue; vertical transmission

Figure 1. Baby with petechial and rash in neonatal dengue

KONIKA XVIII Abstract Book 245