Page 264 - Abstract Book KONIKA 18

Infection & Tropical Disease

P-ITD-019
Zinc Supplementation in Therapy of Dengue Viral Infection
in Pediatric Population: A Systematic Review

Fidel Corona, Jerrell Francie, Clarence Ediana Goestiandi, Susilawati
Department of Child Health, Universitas Atma Jaya Catholic Indonesia, Jakarta, Indoesia

Abstract
Background Dengue virus infection (DVI) is one of the common communicable disease in children and can
cause dengue hemorrhagic fever (DHF). Protecting the community from DVI become one of the sustainable
development goals (SDGs) globally. Zinc is a micronutrient and essential for the immune system. Zinc
deficiencies is associated with impaired innate and adaptive immune responses, and may increase susceptibility
to infection. Objective This study try to review whether zinc supplementation is protective or a risk factor
for the severity of DVI in pediatric population. Methods Systematic searching of the papers was done on
the ProQuest, EBSCO, PubMed and Google Scholar. 79 reports were obtained, 70 papers were excluded.
A systematic review was done to the remaining of the papers. Results The role of zinc supplementation in
therapy of DVI (any grade) is inconsistent. Some studies showed that zinc supplementation for DVI may
contribute to shorten the hospital staying and not contribute to clinical severity of the disease. Conclusion
Zinc supplementation may shorten the hospital staying, but the results are still inconsistent. Further research
on zinc supplementation on DVI should be done more specific in term of duration of supplementation and
its relationship to the virus that can improve the clinical outcome in children.
Keyword: zinc; dengue; infection, pediatric

P-ITD-020
Clinical and Laboratory Profile of Cytomegalovirus Infection in Dr. Wahidin
Sudirohusodo Hospital Period January 2020 - October 2020

Gebi Noviyanti, Ninny Meutia Pelupessy, Husein Albar,Ratna Dewi Artati
Department of Child Health, Faculty of Medicine, Universitas Hassanudin/Dr. Wahidin Sudirohusodo Hospital,
Makassar, South Sulawesi, Indonesia

Abstract
Background Cytomegalovirus (CMV) is a virus belonging to the Herperviridae family that is often found
in the human population. The incidence of congenital CMV is higher in developing countries, about 1-5%
but only about 10% had clinical symptoms. Clinical features of CMV include sensorineural deafness,
cognitive/motor deficits, and visual disturbances. Laboratory findings of CMV infection are elevated
aspartate transferase, conjugated hyperbilirubinemia, thrombocytopenia and elevated cerebrospinal fluid
proteins. Objective This study aimed to know about clinical and laboratory profile of CMV infection in
children Methods An observational was conducted by seeing patient’s medical record. The study population
was all patients with CMV in RSUP Dr. Wahidin Sudirohusodo Makassar from January to October 2020.
Results During this study period there were 18 patients with CMV infection. In this study, the proportion of
girls was slightly higher (55%) with age range was < 6 months (55%) and the majorities of infants born were
aterm and appropriate for gestational age (83.3%). The most prominent clinical manifestation are jaundice
(44.4%), dyspnue (38.9%), hepatosplenomegaly (27,8%), microchepaly (11,1%). Laboratory manifestation
revealed 94.4% of positive IgG. 61.1% of positive IgM, 55.6% of moderate anemia (hemoglobin 7.0-9.9
g/dL), 5.5% of thrombocytopenia, 72.2% of elevated transaminase enzymes and 50% of hyperbilirubinemia.
Conclusion In this study, the clinical manifestation which is mostly found from the physical examination
is jaundice and laboratory examination mostly revealed positive IgG.
Keywords: cytomegalovirus infection; clinical profile; children; laboratory profile

216 KONIKA XVIII Abstract Book