Page 262 - Abstract Book KONIKA 18

Infection & Tropical Disease

P-ITD-015
The Convalescent Plasma-Related Adverse Effect
in COVID- 19 Pediatric Patients with Comorbid

1
Brenda Karina , Yudha Ferriansyah 2
2
Bunda Aliyah Mother and Children Hospital and Yadika Hospital , Jakarta, Indonesia
1
Abstract
Background COVID 19 infection that caused by severe acute respiratory syndrome coronavirus 2 (SARS–
CoV–2) is still continuing to spread worldwide as a severe pandemic. It can leads to pneumonia, multiple
organ failure, and Death. Early identification of COVID-19 and prompt treatment are essential, especially in
children with underlying/comorbid disease(s) can lead to severe course. Objective To know the CP–related
adverse effect for severe cases Covid-19 pediatric patients with comorbid. Methods The study design was
a systematic review that comparing several studies about CP therapy in Covid-19 pediatric patients with
comorbid from 2019-2021 sourced from Pubmed and Google Scholar. Results Based on 216 search results.
5 studies met the inclusion, included: 3 case report and 2 case series. These studies included a total of 20
children diagnosed severe COVID 19 with comorbid and all selected studies provided data on complete
blood count, C-reactive protein (CRP), SARS-CoV-2 RNA – RT-PCR, symptoms, and treatment. Although
adverse reactions can be seen with plasma transfusions, including transfusion related lung injury, transfusion-
associated circulatory overload (TACO), and anaphylaxis, no reactions or complications were seen in
most studies. In a pediatric population, TACO can be a specific concern due to large volume transfusions
in a small weight patient. Conclusion Positive outcomes of the few cases reports published suggest that
convalescent plasma therapy may be of potential benefit, all studies reported no CP-related adverse events
in pediatric patients.
Keyword: COVID-19; covalescent plasma; pediatric; adverse effect

P-ITD-016
Clinical Profiles of Hospitalized Pediatric Patients with COVID-19
in Hermina Hospital Bekasi from January to July 2021

Elizabeth Melina, Agnes Praptiwi, Rinna WS
Hermina Hospital Bekasi, West Java, Indonesia

Abstract
Background High number of COVID-19 cases affected not only adult but also pediatric population.
Data regarding clinical profiles of pediatric patients with COVID-19 in Indonesia were still lacking.
Objective To describe clinical profiles of pediatric patients hospitalized with COVID-19.
Methods This is single-center descriptive study, we collected data from medical records to describe clinical
profiles of pediatrics patients (aged 0-18 years old) who were admitted to our hospital from January to July
2021 and tested positive for SARS-CoV-2 by RT-PCR. Results We reported 62 cases of hospitalized pediatric
patients with COVID-19, four of whom were neonates born to confirmed COVID-19 mothers. We categorized
the patients based on clinical symptoms to asymptomatic (4), mild (4), moderate (49), and severe (5). Most
common symptoms were fever, dyspnea, cough, and diarrhea. One patient was admitted to neonatal intensive
care unit (ICU), 13 patients to pediatric ICU, and 48 patients to isolation ward. Nearly quarter of patients
had comorbidities (n=14, 22.5%) while 12% of patients (n=7) had coincident with other diseases (6 dengue
hemorrhagic fever, 1 bowel obstruction). One case of suspected Multisystem Inflammatory Symptoms
in Children (MIS-C) was reported. Mortality rate in our study was 1.6% (2 patients with comorbidities).
Conclusion Increasing number of COVID-19 cases happened in all aged-group of pediatric population,
from neonates to teenager. Most cases were present with respiratory or gastrointestinal symptoms, however,
coinfection with dengue virus infection must be still considered. Among all pediatric patients, those with
comorbidities should be monitored closely.
Keywords: clinical profiles; COVID-19; pediatrics

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