Page 243 - Abstract Book KONIKA 18

Hemato-Oncology

P-HO-030
Correlation between Clinical and Laboratory Findings with Outcomes
in Children with Acute Myeloblastic Leukemia
at Mohammad Hoesin Hospital Palembang

Sahala Iriawan, Dian Puspita Sari
Department of Child Health, Faculty of Medicine Universitas Sriwijaya, Mohammad Hoesin General Hospital,
Palembang, South Sumatera, Indonesia
Abstract
Background Clinical factors and performance status at diagnosis of acute myeloblastic leukemia (AML) are
associated with remission rates and overall survival. By identified these factors could help the physician to
decide between standard or increased treatment intensity. Objective To analyze the correlation between clinical
manifestations and laboratory findings of AML patients to the outcomes. Methods This cross-sectional study
obtained data of children with newly diagnosed AML at Mohammad Hoesin Hospital Palembang between
2015-2020 from medical records and pediatric’s hematology/oncology registry. Data were processed by chi
square test, t test and mann whitney test. The outcome was remission rate after treatment. Results There
were 108 subjects included in this study; 64 (59.3%) were males. The mean diagnosis age was eight years.
Clinical manifestations at diagnosis were pale 91.7%, fever 66.7%, bleeding 34.3%, joint pain 12%, seizure
4.6%, lymphadenopathy 23.1%, hepatomegaly 39,8%, and splenomegaly 26.9%. Laboratory findings revealed
mean of haemoglobin concentration 7.29 (2.1-14.3) gr/dl, platelet counts 63.854 (2000-1010000) cell/mm3,
leucocytes count 50.901 (614-309800) cell/mm3. Thirty six (33.3%) patients had complete remission, 14
(13.0%) relapsed, 33 (30.6%) deceased and 21 (19.4%) lost to follow up. Regression analyses found that
decreasing haemoglobin concentration had a negative correlation for the outcome of AML (β coefficient
-0.097; OR 0.907; 95%CI 0.792 to 1.039; P=0.161). Conclusion There is no statistically significant correlation
between clinical and laboratory findings to the remission rate.
Keywords: outcome; acute myeloid leukemia; pediatric

P-HO-031
Ewing’s Sarcoma and Pancreatic Metastasis in 14-year-old ld Girl: A Rare Case

I Dewa Ayu Agung Shinta Kamaya, Andi Cahyadi, Maria Christina Shanty Larasati,
Mia Ratwita Andarsini, I Dewa Gede Ugrasena, Bambang Permono
Department of Child Health, Universitas Airlangga/ Dr. Soetomo General Academic Hospital,
Surabaya, East Java, Indonesia
Abstract
Background Ewing’s sarcoma is malignant osteolytic tumor, affects mostly children and adolescent. It
possesses a high potential of metastasis. The most common metastatic sites are the lung, pleura, and bones.
Pancreatic metastasis is quite rare, accounting for only 2% of all pancreatic cancers. Objective To present a
rare case of pancreatic metastasis in 14 years old girl with Ewing’s sarcoma. Case A 14 years old girl initially
diagnosed with Ewing’s sarcoma of the right tibia on June 2020. She underwent surgery, followed by adjuvant
chemotherapy (cyclophosphamide and doxorubicin) for 11 cycles. The evaluation after chemotherapy was
no residual mass and metastasis. Five months after evaluation, palpable masses were found in right femur
and ankle, which biopsy revealed Ewing’s sarcoma. A week later, she complained of nausea and abdominal
pain. She looked jaundice, with increased of ALT, AST, and direct bilirubin. Amylase and lipase level were
294 U/L and 1,363 U/L, respectively. Blood glucose was normal. Abdominal CT scan revealed enhancing
solid masses 5.5x4.8x4.6 cm in pancreas head and 4.1x5.8x6 cm in pancreas body, suggested pancreatic
metastasis. Biopsy and surgery cannot be done because of high risk of complications. She was fasting and
supported with total parenteral nutrition. Within seven days of treatment, jaundice seemed reduce, no nausea
and abdominal pain, ALT, AST, bilirubin, amylase, and lipase level decreased. We planned for chemotherapy
and radiotherapy. Conclusion Although quite rare, pancreatic metastasis should be suspected when patient
with Ewing’s sarcoma complaints of nausea, abdominal pain, jaundice, increased level of amylase and lipase.
Keywords: Ewing’s sarcoma; pancreatic metastasis; child

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