Page 248 - Abstract Book KONIKA 18

Hemato-Oncology

P-HO-040
Survival Rate of Acute Myeloid Leukemia Patients
in Estella Pediatric Center Care Manado

Yosefa Anggi Miranti, Max F.J. Mantik, Stefanus Gunawan
Department of Child Health, Faculty Medicine, Universitas Sam Ratulangi/Prof Dr. R.D. Kandou Hospital,
Manado, North Sumatera, Indonesia

Abstract
Background Prognosis of childhood acute myeloid leukemia has improved significantly to approximately
70% over the recent decades, but there was lack data of survival rate childhood acute myeloid leukemia
in developing countries. Objective To evaluate the survival rate of childhood Acute Myeloid Leukemia
patient with National AML Protocol in Manado. Methods Retrospective, descriptive study from medical
record of acute myeloid leukemia patients in Estella Center Care Manado. The study include all patients
with acute myeloid leukemia, diagnosed between 2011 and 2020, younger than 18 years old. We excluded
patient received others protocol AML and down-syndrome. The diagnosis of AML was confirmed based
on morphological and histochemical examinations of marrow samples. Results There were 26 patients
diagnosed with AML, 9 patients were female and 15 patients were male. Only 24 of 26 patients received
chemotherapy. The death rate was 84.6%, 22 patients died and 4 patients alive. Of the 22 died patients,
16 died during chemotherapy, 5 drop outs and died, 1 suspected relapsed and died. From 4 (15.4%) alive
patients, 3 survived and 1 on chemotherapy. Cause of death mainly due to severe infection as treatment
related death and bleeding due to thrombocytopenia. Conclusion Survival rate of childhood AML patients
in Estella Pediatric Center Care Manado is low.
Keywords: acute myeloid leukemia; survival

P-HO-041
Congenital Leukemia: A Case Report

Emiliana Susanti Foris
Department of Child Health, Dr. TC Hillers General Hospital, Sikka, East Nusa Tenggara, Indonesia

Abstract
Background Congenital leukemia is an extremely uncommon malignancy, occurring at 1 per 5 million births
and represents less than 1% of all childhood leukemia. It is usually diagnosed at birth or within 1-month of
life and may be associated with syndromic conditions including Down’s syndrome. Here we report a case
of congenital leukemia in a one-day-old boy with Down’s syndrome.Objective We present this rare case
to generate awareness about Congenital Leukemia in newborn and differentiation from other conditions
mimicking leukemia. Case A newborn boy was admitted with respiratory distress and grunting begun since30
minutes after birth. He was a preterm neonate, 36 wks with birthweight of 2000 gram born by spontaneous
labour, from a 43-year-old healthy mother with no significant finding in her past medical history. Parents
were unrelated, and there was no history of cancer within their family. Physical examination showed that
the patient was lethargy, febrile and pale with facial syndromic appearance suggestive for Down’s syndrome
including eye epicanthus, flat nasal bridge, low set ear and neck webbing. He had tachypnea and rales in
the chest. Our case was investigated for suspicion of early sepsis, low birthweight, and respiratory distress
showing severe leukocytosis (387.90 10³/uL). The peripheral blood smear showed atypical cells (91%
blast cell). Bone marrow aspirate and karyotyping are not able to be performed in our hospital. Conclusion
Leukemia should be considered in such conditions presenting clinical features of sepsis and leukocytosis
besides having an alert look for associating abnormalities.
Keywords: congenital leukemia; Down’s syndrome

200 KONIKA XVIII Abstract Book