Page 236 - Abstract Book KONIKA 18

Hemato-Oncology

P-HO-017
Prevalence and Associated Factors of Low BMD and Osteoporosis
in Thalassemia Major Patients in Cipto Mangunkusumo Hospital

1
1
Felicia Sidarta , Pustika Amalia Wahidiyat , Aman Bhakti Pulungan , Damayanti Sekarsari 2
1
1
Department of Child Health and Department of Radiology , Faculty of Medicine, Universitas Indonesia,
2
Jakarta, Indonesia
Abstract
Background Osteoporosis is an important cause of morbidity in thalassemia major patients. The global
prevalence of osteoporosis in well treated thalassemia major patients is approximately 40–50%, but it is
still unknown in Indonesia. The lack of early diagnosis of low bone mineral density (BMD) and treatment
has led to increased morbidity and lowered quality of life. Objective To determine the prevalence of
low BMD and osteoporosis in thalassemia major patients aged 7-12 years and correlation between BMD
and mean pretransfusion hemoglobin, mean serum ferritin, vitamin D, ionized calcium, and duration of
the disease. Methods This study was cross-sectional, conducted on 50 thalassemia major patients, aged
7-12 years in Cipto Mangunkusumo Hospital (CMH). The BMD was measured by GE lunar DXA in
radiology department of Kencana CMH. The data of pretransfusion hemoglobin, serum ferritin, ionized
calcium, and spine x-ray were attained from electronic health record and vitamin D from Prodia laboratory.
Results The prevalence of low BMD in thalassemia major patients aged 7-12 years is 52%, and the prevalence
of osteoporosis is 20%. The prevalence of osteopenia based on spine x-ray is 94%. Conclusion There was
no correlation between BMD and mean pretransfusion hemoglobin, mean serum ferritin, vitamin D, ionized
calcium, and duration of the disease.
Keywords: bone mineral density; osteoporosis; prevalence; thalassemia major

P-HO-018
Inconsistency in the Diagnosis of Referred Children with Cancer
at the Hasan Sadikin General Hospital, Bandung during 1-year period
Eva Rosiyana Dewi, Susi Susanah, Nur Suryawan, Nur Melani Sari
Department of Child Health, Faculty of Medicine, Universitas Padjajaran, Bandung, West Java, Indonesia
Abstract
Background Cancer is a rare condition among children. Cancer often presents with nonspecific symptoms
which lead to delay in diagnosis and treatment. Objective To investigate an inconsistency in the diagnosis
of referred children with cancer transferred to Hasan Sadikin General Hospital (HSGH) between July 2020
– June 2021. Methods A cross sectional study using historical data was conducted at HSHG between July
2020 to June 2021. Demographic, initial diagnosis, number of visits and final diagnosis were collected. The
data was then analyzed using SPSS version 23. Results A total of 197 patients recruited. The age range was
1 to18 years old, with the average 7.6 years. There were 92 females (46.7%) and 105 males (53.3%). The
prevalence of misdiagnosis is 31.5%. The most frequent of diagnostic error made by sender when referring
the patients to HSGH was anemia gravis which then diagnosed as acute lymphoblastic leukemia high risk
(11.29%) in. Second most frequent diagnostic error was Myelodysplasia Syndrome which then diagnosed
as Acute Lymphoblastic Leukemia standard risk (8.06%), and Aplastic anemia that the final diagnosis
become Myelodysplasia syndrome (5%). Pediatricians is the most common profession who referred the
patient (74,2%), followed by general practicioners (24,2%) and surgeons (1,6%). The average number of
patients’ visits were twice with a range of 1-16 visits, almost all of them are diagnosed at the first visit.
Conclusion It is essential that the primary care physicians have a sufficient knowledge and skill to identify
signs and symptoms of cancer in children.
Keywords : inconsistency referral diagnosis; cancer in children; Hasan Sadikin Hospital

188 KONIKA XVIII Abstract Book