Page 231 - Abstract Book KONIKA 18

Hemato-Oncology

P-HO-010
The Relationship between Serum Ferritin and Liver Enzymes,
and the Profiles of the Duration of Transfusion with Serum 25(OH)D
in Children with Thalassemia Major at Dr. Cipto Mangunkusumo Hospital

Betti Danil, Hartono Gunardi, Aman B. Pulungan, Pustika Amalia Wahidiyat
Department of Child Health, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital,
Jakarta, Indonesia
Abstract
Background The first organ affected by iron overload due to routine transfusion in children with thalassemia
major is the liver, which will cause damage to organ functions, such as serum 25(OH)D metabolism.
Objective This study aims to determine serum ferritin levels, transaminase enzyme, and duration of
transfusion with serum 25(OH)D in children with thalassemia major. Methods A cross sectional study was
conducted on 64 thalassemia major children, aged 7-12 years, from November to December 2020 at Dr. Cipto
Mangunkusumo (CMH). Serum ferritin, CRP, transaminase enzyme, and serology hepatitis marker were
examined in the laboratory of CMH. Serum 25(OH)D examination using ELFA method was carried out at
the Kalgen Innolab Jakarta. Results From 64 subjects, mean serum ferritin 5537.85±2976.17 ng/mL. CRP
was 0,9 (1-10) mg/dL and serology hepatitis B and C were non-reactive. Transaminase enzyme increased
(2-4 times the upper reference limit) in 9,4% and (>4 times) in 6,25% of subjects. Correlation between serum
ferritin and AST (r =0.462) and for ALT (r = 0.511), P <0.05. Mean serum 25(OH)D 15.556±5.825 ng/mL,
range (8.09-27.5 ng/mL), with deficiency status in 34.4% and insufficiency in 45.3% of subjects. Patients
with a duration of transfusion ≥ 8 years show a high incidence of vitamin D insufficiency and deficiency.
Conclusion The correlation between serum ferritin and transaminase showed a moderate corelation; was
statistically significant. The increase in serum ferritin and the prevalence of serum 25(OH)D deficiency in
children with thalassemia major requires further management to improve general health, reduce iron overload
and other related potential complications.
Keywords: serum ferritin; thalassemia major; iron overload; serum 25(OH)D; ALT; AST

P-HO-011
Clinical Characteristics of Acute Lymphoblastic Leukemia Patients
in Harapan Kita Children and Women Hospital

Dina Garniasih, Fajar Subroto, Nia Astarina, Akhil Deepak Vatvani
Department of Child Health, Hematology Oncology Division, PKIAN RSAB Harapan Kita, Jakarta, Indonesia

Abstract
Introduction Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, constitutes
up to 75% of all cases. ALL is a result of clonal proliferation of early lymphoid precursors with arrested
maturation. Clinical characteristics of ALL patients are variative. Data from developing countries such
as Indonesia is still limited. Objective To describe the characteristics of ALL patients in our hospital.
Methods This is a retrospective study that took place in national referral hospital in Jakarta. Patients of year
2019 were included. Data was taken from medical records. Data such as initial presentation and outcome
was noted. Analysis was done using descriptive statistics. Results A total of 41 children were included, out
of which 30 (73.1) were male. Mean age of the patients were 4.5 (SD 3.7) years. 21 (51.2%) of patients had
normal nutritional status. Thirty-eight (92.7%) were of B-cell lineage. Total of 32 (78%) were characterized
as high risk. Initial median WBC count was 30.3 (1.1-333.1) 103/μL. Initial median thrombocyte count was
91.8 (9-532) 103/μL. Initial mean blast count 59.9 (SD 36.7) %. Most common symptom was fever (61%),
followed by bleeding tendencies (31.7%). All patients completed induction successfully. Relapse occurred
in a total of 15 (36.5%) patients within 1 year. Conclusion In our study, B-cell ALL was the most common
type. The relapse rate is high (36.5%).
Keywords: acute lymphoblastic leukemia; clinical characteristics

KONIKA XVIII Abstract Book 183