Page 209 - Abstract Book KONIKA 18

Endocrinology

P-ENDO-065
Evaluation of Thyroid Hormone Status in Children with Type 1 Diabetes Mellitus

Agniya Ali Fahmi Hikmat, Garindra Wicaksono, Muhammad Faizi, Nur Rochmah
Department of Child Health, Faculty of Medicine Universitas Airlangga/Dr.Soetomo General Academic Hospital,
Surabaya, East Java, Indonesia

Abstract
Background Several studies have reported that the risk of thyroid dysfunction in patients with type 1 diabetes
mellitus (T1DM) is two to threefold higher than in general population. Assessment of thyroid hormones
level in children with T1DM can be investigated for detection of thyroid related disorders. Objective To
evaluate thyroid hormones in children with T1DM. Methods A cross-sectional study was conducted at
Pediatric Endocrinology outpatient clinic at Dr Soetomo Hospital on children with T1DM aged 3-18 years.
The levels of thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were measured. The cut-
off values for thyroid hormones are based on American Academy of Pediatric guidelines. Pearson’s test and
chi-square’s test was conducted with a significance value of P<0.05. Results A study included 31 children
with T1DM, 17/3 were males. The mean of age, BMI, duration of illness, and HbA1C was 11.2±3.7 years,
16.4±4.2, 34.12±30.6 months, and 7.5±3% respectively. There were 28/31 children with euthyroid, 3/31
children with subclinical hypothyroidism, and none experienced hyperthyroidism. There was no correlation
between HbA1C and TSH levels in T1DM (P=0.181;r=0.247) and HbA1c with FT4 levels (P=0.979;r=-0.005).
There was no correlation between HbA1C levels and hypothyroidism in children with T1DM (P=0.394).
There was no correlation between duration of illness of T1DM and hypothyroidism (P=0.436).
Conclusion The thyroid dysfunction was observed in T1DM. Therefore, thyroid hormone status in children
with T1DM needs to be evaluated regularly.
Keywords: type 1 diabetes mellitus; thyroid dysfunction; children

KONIKA XVIII Abstract Book 161