Page 206 - Abstract Book KONIKA 18

Endocrinology

P-ENDO-059
Quality of Life Among Children with Osteogenesis Imperfecta

Rahma Ira Mustikasari, Nur Rochmah, Muhammad Faizi, Irwanto.
Department of Child Health, Faculty of Medicine Universitas Airlangga, Surabaya, East Java, Indonesia

Abstract
Background Quality of Life (QoL) is an important parameter to evaluate the management in
Osteogenesis Imperfecta (OI). Individuals with OI require complex medical and social care. The study
of QoL among OI children in Indonesia is scarce. Objective To determine quality of life among children
with OI. Methods The cross-sectional study was conducted in Endocrinology Outpatient Clinic at
Dr. Soetomo Hospital Surabaya. QoL was evaluated with Pediatric Quality of Life Inventory (PedsQL)
4.0 Generic Core. The physical, emotional, social and school functioning were used as point of view.
Results There were 29 patients with OI, 17/29 girls and 12/29 boys, age average was 6.9 years. The mean
of fracture event among OI children was 2.3 times per year and the mean of zolendronic acid treatment
was 6.7 times. The most common of fracture was femur, 23/29 of the children. The result showed that the
physical, emotional, social and school functioning were average of 49.6, 65.3, 60.5 and 68.4 respectively.
The physical, emotional, and school functioning were significantly different between frequency of fracture
in last one year of less than 3 times versus 3 times or more (P< 0.05). The significant difference was
also identified in emotional functioning among age group, especially in older age (8-13 years) (P<0.05).
Conclusion Quality of life among children with OI is low. The more prevalent of fracture evidence have an
impact on lower physical, emotional, and school functioning, whereas emotional functioning needs special
requirement in older OI children.
Keywords osteogenesis imperfecta; quality of life; PedsQL

P-ENDO-060
Management and Treatment of Graves’ Disease in Children at the Rural Area:
A Case Report

Vennia Riskia Tristianti , Rosalia Theodosia Daten Beyeng 2
1
2
General Practitioner and Pediatrician , Department of Child Health, Lewoleba General Hospital,
1
Lembata Regency, East Nusa Tenggara, Indonesia
Abstract
Background Graves’ disease is the most common cause of hyperthyroidism. This is a rare case but
may cause serious complication in childhood. ln Indonesia, the incidence is about 1:100.000 children.
Therefore, to prevent these complications, early detection is essential to give prompt and proper treatment.
Objective To diagnose and treat an eleven-year-old girl with Graves’ disease at a rural area. Case An eleven-
year-old girl was admitted to the hospital with a lump on her neck since one month ago. The symptoms
were palpitation, tiredness, lack of concentration, sleeping difficulty, significant weight loss, and resting
tremor. On physical examination, there was an enlarged, palpable mass with the size of 5x3x2 cm on her
neck. The thyroid function tests showed the thyroid-stimulating hormone (TSH) level <0.003 µIU/mL
(normal: 0.47-4.13 µIU/mL) and the free thyroxine (FT4) level 3.37 ng/dL (normal: 0.78-1.31 ng/dL). The
ultrasonography examination of the neck was consistent with Graves’ disease. She was given propylthiouracil
and propanolol. After one month, the symptoms decreased and the thyroid function tests were back to normal.
Conclusion Early diagnosis of Graves’ disease is very important. Graves’ disease treatment using
propylthiouracil increase the risk of liver injury. For this patient, propylthiouracil was given with close
monitoring because methimazole, as the first-line therapy, is not available in a rural area, especially our
regency, Lembata. It’s such a great challenge to diagnose and treat Graves’ disease at rural area.
Keywords: Graves’ disease; hyperthyroidism; propylthiouracil

158 KONIKA XVIII Abstract Book