Page 208 - Abstract Book KONIKA 18

Endocrinology

P-O-063
Caudal Regression Syndrome in the Baby of A Mother with Gestational Diabetes:
A Rare Case Report

Annisa, Stephanie Adelia, Agustini Utari
Child Health Department, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital,
Semarang, Central Java, Indonesia

Abstract
Background Caudal regression syndrome is a congenital malformation with a low incidence in the general
population. It can be associated with diabetic embryopathy from uncontrolled gestational or pre-gestational
diabetes. Objective To report a baby with caudal regression syndrome. Case A-two months-old male baby,
born by cesarean delivery at 36 weeks. His mother had gestational diabetes and only got insulin therapy
from one month of pregnancy until two months and lost to follow up. The baby came to the pediatric clinic
due to multiple congenital anomalies and growth faltering. We found microcephaly, cleft palate, anotia,
unpalpable anterior superior iliac spine, unpalpable right testicle, and micropenis in physical examination.
Abdominal ultrasound showed unilateral renal agenesis and unilateral cryptorchidism. The skeletal survey
revealed microcephaly with brachycephalic type, the fusion of right costae 3 and 4 posterior, pelvic
hypoplasia, and absence of lumbar vertebrae, sacrum, coccygeus, and ischium. Echocardiography showed a
normal finding. Therefore, we suggest the diagnosis in this infant was a caudal regression syndrome due to
diabetic embryopathy. Conclusion A caudal regression syndrome may be related to diabetic embryopathy.
Hyperglycemia is the major teratogen, and it is crucial to control blood sugar levels to reduce congenital
anomalies.
Keywords: congenital malformation; sacral agenesis; caudal regression syndrome; diabetic
embryopathy

P-ENDO-064
GAD65 Antibody Prevalence and Correlation with HbA1C and C-peptide
in Children with Type 1 Diabetes Mellitus

Nurani Widianti, Garindra Wicaksono, Nur Rochmah, Muhammad Faizi
Department of Child Health, Faculty of Medicine Universitas Airlangga/Dr.Soetomo General Academic Hospital,
Surabaya, East Java, Indonesia

Abstract
Background A higher prevalence of Glutamic Acid Decarboxylase 65 Antibody (GAD65Ab) has been
seen in several studies of patients with type 1 diabetes mellitus (T1DM). Moreover, GAD65Ab, HbA1C,
and C-peptide have an essential role in T1DM. Objective To establish the prevalence of GAD65Ab and the
correlation of GAD65Ab with HbA1C and C-peptide levels in children with T1DM. Methods A cross-sectional
study was conducted from January-June 2019 at the Pediatric Endocrinology outpatient clinic of Dr.Soetomo
Hospital in children with T1DM aged 3-18 years. The levels of GAD65Ab, HbA1C, and C-peptide were
measured. The cut-off levels were based on the American Academy of Pediatric guidelines. Spearman's
test was performed with a significance value of P<0.05. Results Thirty-one children with T1DM were
enrolled in this study. There were 28/31 children with a positive level of GAD65Ab and the same proportion
of gender. The mean age, duration of illness, HbA1C, and C-peptide were 11.2±3.7 years, 34.12±30.6
months, 8.67±2.1 IU/mL, and 0.21±0.5 ng/mL. There was no correlation between GAD65Ab and HbA1C
levels in T1DM (P=0.801;r=0.047) and GAD65Ab with C-peptide levels in T1DM (P=0.858;r=-0.034).
Conclusion GAD65Ab was present in children with T1DM. HbA1C and C-peptide levels were not correlated
with GAD65 levels in children with T1DM.
Keywords: type 1 diabetes mellitus; GAD65 antibody; HbA1C, C-peptide

160 KONIKA XVIII Abstract Book