Page 152 - Abstract Book KONIKA 18

Developmental Behavioral & Community Pediatrics

P-DBCP-041
Measles Containing Vaccine in Children
to Prevent Coronavirus Disease 2019 Mortality and Morbidity

1
2
Diandra Tatiana , Felicitas Anindya Utami , Yoga Devaera 3
1
Hermina Kemayoran Hospital , IMUNI Vaccination Clinic , Department of Child Health, Faculty of Medicine
2
Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital , Jakarta, Indonesia
3
Abstract
Background Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) virus or Novel Coronavirus
has growing prevalence in children while no vaccine available yet for under 12-year-old. Novel-alpha-corona
viruses and paramyxoviruses (measles family) share cocirculation viral strains. In addition, the amino acid
sequence homology between the COVID-19 virus and the rubella virus very similar this may elicit cross-
immune reactivity. Objective To assess the role of measles containing vaccine (MCV) vaccine in preventing
COVID-19 in children. Methods Patient/problem, intervention, comparison, and outcome (PICO) system
were used. We conduct Electronic-literature researches using PubMed, Cochrane, and Google Scholar with
keywords “MCV vaccine” AND “COVID-19 children” AND “mortality” AND “morbidity”. We include
case control, clinical trial, cohort studies for age 1 to18-year-old. Results Two studies met inclusion criteria.
Pawlowski et.al found administration of the MMR vaccine (RR 0.56; P=0.0032), was associated with lower
infection rates. Meanwhile Gujar et.al found, MCV 87.5% (OR 0.125, 95%CI) was associated with mild
symptoms (P<.0001) of Covid-19. No study reported mortality. Conclusion The MCV vaccine have potential
in prevent COVID-19 infection directly. MCV Vaccine also have potential in reduces COVID-19 infection
rates and decrease manifestations of COVID-19 infection.
Keywords: measles containing vaccine; COVID-19; SARS-CoV-2; children

P-DBCP-042
Quality of Life in Children with Chronic Disease in Malang City Using
Assessment Pediatric Quality of Life Inventory™
Irfan Agus Salim, Yaalmolly Vinothini Ravindran, Haryudi Aji Cahyono, Fadhilah Muttaqin
Departemen of Child Health, Faculty of Medicine, Universitas Brawijaya/Dr. Saiful Anwar General Hospital,
Malang, East Java, Indonesia
Abstract
Background Chronic disease is known as a condition that affects the work function or activity of daily living
that causes a person tend to hospitalization. Children who have chronic diseases will be more frequently
hospitalized for treatment and medical check-up visits. Chronic diseases can influence quality of life and
development of children. Objective To find out the quality of life in children with chronic disease in Malang
City using assessment PedsQL™. Methods An observational research with cross sectional method. Sampling
was taken by applying purposive or non-probability sampling with a sample of 82 respondents. Correlating
the type of disease, nutritional status, age, sex, knowledge and parental education, length of illness with
the quality of life by using assessment pediatric quality of life inventory (PedsQL). Statistical analyzing
using Spearman correlation. Results The results showed the factors which are significantly corelated (P<
0.05) to a child's quality of life are type of diseases (P=0.005) and nutritional status of the child (P= 0.009),
while the others factors are sex (P=0.223) , knowledge (P=0.544) and parent’s education (P-value= 0.366),
length of illness (P=0.162), social and economic condition (P=0.1000) and number of children (P=0.364)
not significantly related to quality of life. Conclusion There are significantly corelated between nutritional
status, the type of disease with quality of life in children with chronic disease.
Keywords: chronic disease; PedsQLTM; quality of life in children

104 KONIKA XVIII Abstract Book