Page 116 - Abstract Book KONIKA 18

Allergy Immunology

P-AI-027
Relationship between 25-hydroxyvitamin D (25 (OH) D) Levels and Systemic
Lupus Erythematosus Disease Activity in Children

Halida Rahmah Nasution, Lily Irsa, Yunnie Trisnawati
Department of Pediatric Health, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia

Background The level of 25(OH)D in SLE children varies depending on UV exposure and drugs used in
the treatment of SLE. There are reports that these levels are influenced by disease activity. SLE disease
activity can be assessed, one of which is the SLEDAI score. Objective To determine the relationship between
25-hydroxyvitamin D (25 (OH)D) levels with disease activity in the SLE as assessed by the SLEDAI score.
Methods This study was an observational analytic study with a cross-sectional design in children aged 5-18
years at H. Adam Malik General Hospital Medan from April to May 2019. The SLEDAI score and 25(OH)
D level were assessed when the patient visited and was treated at the hospital. The data were analyzed
statistically using the Pearson test. Results A total of 30 research subjects had met the inclusion criteria,
93.3% were women with the most common age being 10-14 years. The 25 (OH) D level value was 14.9 ±
6.6. Disease activity in LES assessed by SLEDAI score was mostly found in high activity group patients
with average score of 11.7±8.9. The highest frequency of SLEDAI scores was in the kidney organ where
66.7% of the sample had hematuria, 60% had pyuria, 43.3% had cylindrical symptoms in the urine, and
23.3% had proteinuria. The 25 (OH) D levels with SLEDAI scores had a negative correlation (r= -0.284,
P>0.05). Conclusion There is no significant correlation between 25(OH)D level and SLE disease activity.
Keywords: 25 (OH) D level; SLEDAI score; systemic lupus erythematosus

P-AI-028
Clinical Characteristics of Rheumatic Disease in Children in
Dr. Soetomo Hospital Surabaya

Ratih Kumala Sari, Azaria Amelia Adam, Diah Budiarti, Zahrah Hikmah,
Azwin Mengindera Putera Lubis, Anang Endryanto
Department of Child Health. Faculty of Medicine Universitas Airlangga/Dr. Soetomo General Academic Hospital,
Surabaya, East Java, Indonesia
Abstract
Background Rheumatic disease in children usually results in significant impairment in quality of life,
morbidity, and mortality. Rheumatic disease data in children from developing countries like Indonesia
are limited. Objective To describe demographic, clinical profile, and management of rheumatic disease in
children as this can provide comprehensive evidence-based health care services. Methods This descriptive
retrospective study was conducted at Dr.Soetomo General Hospital Surabaya, Indonesia. Data were collected
from medical record of Allergy and Immunology outpatient clinic patients between years 2014 and 2019.
Clinical characteristics, laboratory findings and therapy of all children with rheumatic disease were evaluated.
Microsoft Excel and SPSS 21 were used for data analysis.Results A total of 140 children with various
rheumatic diseases were included in the study. Childhood onset of Systemic Lupus Erythematosus (SLE) was
the most common pediatric rheumatic disease observed (50%). The following rheumatic diseases are Henoch-
Schonlein Purpura (29%) and Juvenile Idiopathic Arthritis (20%). Female to male ratio was 1.5:1. The median
age of disease onset was 9 years old. Most common chief complaints were rash (34.3%), arthralgia (17.8%),
and fever (16.4%). Positive ANA test was in 41 patients with SLE and one patient with JIA. Oral steroids
were mostly administered, following with intravenous steroids, NSAIDs, and other immunosuppressant.
Conclusion Most common rheumatic disease in children was SLE, followed by HSP. Female was more
frequent. Most common chief complaint was rash. Management of rheumatic disease included oral steroids.
Keywords: rheumatic disease; pediatric, systemic lupus erythematosus; Henoch-Schonlein purpura;
juvenile idiopathic arthritis

68 KONIKA XVIII Abstract Book