Page 111 - Abstract Book KONIKA 18

Allergy Immunology

P-AI-017
Inherited Recessive Dystrophic Epidermolysis Bullosa in Monozygotic Twins

1
Deon Raditya Hibbattino , Nurani Widianti , Zahrah Hikmah , Irmadita Citrashanty 2
1
1
2
1
Department of Child Health and Department of Dermatology and Venereology , Faculty of Medicine Universitas
Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia
Abstract
Background Epidermolysis bullosa (EB) is a rare blistering disorder that can be inherited and has a wide
spectrum of clinical presentations. with the incidence estimated at around 1/50000. Only 5 cases were ever
reported in twin patients. EB can be inherited either as autosomal dominant or recessive trait. We report a
twin both affected with recurring blistering skin since birth. Objective To present a rare case of EB in twin
patients. Case An identical 4-month-old twin brother was presented with recurrent symptoms of skin blisters
since birth. The blisters were localized without any history of trauma or pressure, seems to be limited and
mainly found in acral and fingers. The twin with milder symptoms presented skin blistering restricted to
exposed area, whereas severe blisters, erosion, ulceration, marked inflammation, and blackened lesion affect
the extremities of the older twin with more severe clinical manifestations. Blisters heal with scarring in some
areas. There were no known consanguinities and family history of EB. Skin swab culture of blackened lesion
was detected Staphylococcus aureus and treated with antibiotic, but the blister persisted. A skin biopsy was
performed on both twins. The histopathologic study revealed a subepidermal blister with variable inflammation
and lymphocyte infiltration, which confirmed dystrophic type of EB in the twin’s patients. Conclusion EB
in twins is a clinical interest diagnosis due to its rarity and recurring symptoms. In our case, the disease was
passed down hereditary recessively and affect both of the twins with different symptoms.
Keywords: epidermolysis bullosa; identical twins; blister; skin biopsy

P-AI-018
The Role of Bifidobacterium breve as Prevention of Allergies in
Paediatrics Diseases

Raka Novadlu Cordita, Tasya Khalis Ilmiani, Nadira Rahil Rachmawani
Faculty of Medicine, Universitas Lampung, Bandar Lampung, South Sumatera, Indonesia
Abstract
Background Allergic disease in children is one of the diseases whose prevalence has increased in recent
decades. The gut microbiota that formed at birth can help the protection and development of allergies in
paediatrics. Objective To determine the effect of Bifidobacterium breve in preventing allergies in paediatrics
diseases in non-breastfed infants in early life. Methods This study uses a systematic review method by
searching literature studies using keywords according to the topic. For this study, the inclusions criteria are the
use of probiotic Bifidobacterium breve in infants who did not breastfeed, in newborns using antibiotics or by
caesarean section, and infants with allergy to cow's milk. The exclusion criteria are newborns who were born
normal and breastfed. There are eight journals selected for this study and all journals were collecting from
Google Scholar and PubMed. Results For this study, there are eight journals selected. These journals are a
case study, article review, observational, and systematic review that discusses the effects of Bifidobacterium
breve in preventing allergies in paediatrics diseases. The results show that Bifidobacterium breve may provide
allergy prevention benefits in infants who did not breastfeed, in newborns using antibiotics or by caesarean
section, and protects against the development of allergy to cow's milk. Conclusion Bifidobacterium breve
probiotics can be preventing the incidence of allergies in paediatrics diseases.
Keywords: Bifidobacterium breve; allergy; prevention; probiotics; paediatrics

KONIKA XVIII Abstract Book 63