Page 119 - Abstract Book KONIKA 18

Cardiology

P-CAR-005
Successful Medical Treatment of Closing Patent Ductus Arteriosus
in Preterm Neonates: Case Series

Marcella Trixie Kartika, Agung Hari Wibowo, Aldilla Vidya, Gatot Irawan Sarosa, Anindita Soetadji
Department of Child Health, Faculty of Medicine Universitas Diponegoro, Semarang, Central Java, Indonesia

Abstract
Background Patent ductus arteriosus (PDA) is a common problem in preterm neonates. Prolonged PDA
in preterm neonates can be associated with respiratory distress syndrome and necrotizing enterocolitis.
Administration of ibuprofen and paracetamol showed satisfactory result for PDA closure. Objective To report
successful medical treatment for closing PDA using ibuprofen and paracetamol. Case 1 A 35-days-old girl
with oxygen dependency. She was born at 32weeks of gestation, BW 1750gr. Chest retraction happened
when oxygen not given. Physical examination showed continuous murmur on left infraclavicular area. No
tachypnea, rales,or hepatomegaly. Echocardiography showed PDA(1.4mm). Ibuprofen was given 10 mg/kg/
day (day-1) followed by 5 mg/kg/day until six days. After 7 days of ibuprofen, chest retraction disappeared
without oxygen supplementation and no murmur was heard. Echocardiography evaluation showed PDA has
been closed. No side effects were observed. Case 2 A 10-days-old boy have clinical signs of heart failure
including tachypnea and tachycardia. Heart rate (HR) was 180 beats/min. He was born at 27weeks of
gestation, BW 1000gr. Physical examination showed systolic murmur on left infraclavicular area. No rales,
hepatomegaly,or wet skin. Echocardiography showed significant PDA(2.5mm). Paracetamol was given 15
mg/kg/6 hours for seven days to close PDA. Furosemid was also given 1 mg/kg/8 hours as antifailure-agent.
After 6 days of paracetamol, no murmur was heard,and HR decreased to 150 beats/min. Echocardiography
evaluation showed PDA has been closed. No side effects were observed. Conclusion PDA in preterm infants
have been successfully closed with ibuprofen and paracetamol.
Keywords: PDA, preterm neonates, ibuprofen, paracetamol, low birth-weight

P-CAR-006
The Role of Troponin T in Diagnosis of Congenital Heart Disease in Neonates in
H. Adam Malik General Hospital Medan

Yanita Fildzania, Tina Christina L. Tobing, Bugis Mardina Lubis
Department of Child Health, Faculty of Medicine Universitas Sumatera Utara, Medan, North Sumatera, Indonesia

Abstract
Background Congenital heart disease (CHD) are structural abnormalities of the heart or intrathoracic great
vessels occurring during fetal development. Congenital heart disease can be subdivided in non-cyanotic
CHD and cyanotic CHD. Troponins T and troponin I are cardiac regulatory proteins that control the calcium
mediated interaction between actin and myosin. The measurement of serum troponin is superior in terms of
sensitivity and specificity to cardiac muscle enzyme measurements in the identification of myocardial function.
Objective To assess the role of troponin T in diagnosing congenital heart disease in neonates. Methods A
crosssectional study for neonates suffering from congenital heart disease in the intensive care unit (NICU)
and perinatology room. Sampling was conducted in November 2019 - January 2020 with consecutive
sampling technique in neonates with congenital heart disease and healthy neonates based on history, physical
examination, and echocardiography. The value of the diagnostic test was performed to assess assess the
role of Troponin T in diagnosing congenital heart disease in neonates. Results Troponin T levels have good
sensitivity (73.1%), specificity (100%), negative predictive values (78.6%) and positive predictive values
(100%) in diagnosing CHD. Conclusion Troponin T can be used to diagnose CHD and distinguish neonates
who have CHD or not.
Keywords: neonates; troponin T; congenital heart disease

KONIKA XVIII Abstract Book 71