Page 179 - Abstract Book KONIKA 18

Endocrinology

P-ENDO-005
Profiles of Hypotiroid in Preterm infant in Saiful Anwar Hospital

Nur Hidayati Azhar, Harjoedi Adji Tjahjono, Irfan Agus Salim, Fadilah Mutaqin
Departemen of Child Health, Faculty of Medicine Universitas Brawijaya/Saiful Anwar General Hospital,
Malang, East Java, Indonesia
Abstract
Background The clinical signs of hypothyroidism in the neonate are often not clearly enough. Early diagnosis
is very important to prevent the onset of mental retardation or reduce the degree of mental retardation.
Objective Preterm Infant (Juni 2020 to march 2021) were divided evaluated of screening test of TSH and FT4
Level depend on gestational age. Results Of preterm Infant, survivors were enrolled. 30 % (9/27) of enrolled
subjects exited thyroid dysfunction requiring thyroid hormone replacement. The subjects in the treatment
group exhibited lower FT4 level (Mean : 0,55 ng/dL). 55 % (5/9) were in very preterm group and 45% (4/9)
were in moderate to late preterm group. From birth weight. 66,67% (6/9) in low birth weight and 33,33%
(3/9) in very low birth weight. Apgar score, antenatal steroids therapy, respiratory distress syndrome, patent
ductus arteriosus, sepsis, intraventricular hemorrhage, postnatal steroids therapy, and duration of mechanical
ventilation did not differ between the two groups. Infants with smaller for gestational age were more frequent
in the treatment group. Conclusion Physicians should not rule out suggested hypothyroidism, even when
thyroid function of a newborn screening test is normal. We suggest retesting TSH and free thyroxine in high
risk preterm infants with an initially normal TSH level using a newborn screening test.
Keywords: preterm infant; conginetal hypotiroidsm; screening test

P-ENDO-006
Clinical and Laboratory Profiles of Patients with Type 1 Diabetes Mellitus
at Muhammad Hoesin Hospital during COVID-19 Pandemic

Marselya Ulfa, Yulisnawati Hasanah,Aditiawati
Department of Child Health, Faculty of Medicine Universitas Sriwijaya, Mohammad Hoesin General Hospital,
Palembang, South Sumatera, Indonesia
Abstract
Background The government policy limiting activities in public places during the COVID-19 pandemic has
made it difficult for parents to bring their children to the hospital. This policy may impact type 1 diabetes
mellitus (T1DM) patients' access to insulin, regular monitoring of glycemic control, and increase long-term
complications. Objective To assess the clinical and laboratory profiles of children with T1DM during the
pandemic.Methods We reviewed the medical record of patients with T1DM hospitalized at Mohammad
Hoesin Hospital between March 2020-2021, we using independent sample T-test. Results There were 44
patients during the pandemic, six new cases, and 38 old patients; twenty-six were female. Two new cases were
<10 years old and four ≥10 years old; four had DKA, one had thalassemia, and the other had SLE. The serum
c-peptide level of all new patients was <2 ng/mL, and HbA1c level range was 10.3-16.7%. Total routine
visits of 38 old patients before and during pandemic were 334 vs. 179 (range 8-9 vs 4-5) times/year. The
commonest complications were history of hypoglycemia (10) and episode of DKA (6). The mean difference
in HbA1c level of old patient before and during pandemic were 11.1±1.94% vs. 11.24±1.10%, respectively
(P=0.678). There were 26 old patients with increased body weight with IMT value range 19.67-24.78, obese
7.69%, overweight 23%, normal weight 69%. Conclusion There were six new T1DM cases, and almost all
came with DKA. There is no mean difference of HBA1c level before and during pandemic of old patients
and routine control was decreasing.

Keywords: type 1 diabetes mellitus; clinical profiles; complication; HbA1C; COVID-19 pandemic

KONIKA XVIII Abstract Book 131