Page 178 - Abstract Book KONIKA 18

Endocrinology

P-ENDO-003
Correlation of Electrolyte Imbalance with Thyroid Function in Hypothyroid
Children at Saiful Anwar Hospital Malang Indonesia

2
Fauziah Putri Paramita , Harjoedi Adji Tjahyono , Irfan Agus Salim , Fadilah Mutaqin 2
1
2
Resident of Pediatric Department and Endocrine Division, Pediatric Department ,
1
2
Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia
Abstract
Background Thyroid hormone is a central regulator of body functions, it regulates the activity of sodium
potassium pumps in most of the tissues. Disorders of thyroid function are considered to be a cause of
electrolyte disorders. Only few data on the association between thyroid function and electrolyte disorders
exists. Objective To see correlation of electrolyte imbalance with thyroid function in hypothyroid children
in Saiful Anwar Hospital Malang. Methods We conducted retrospective analysis study from all pediatric
patients admitted to the Saiful Anwar Hospital between 1 May 2021 to 31 June 2021, with hypothyroid
function result. TSH, fT(4) and electrolytes serum were examined. Clinical and laboratory data were obtained
from medical records. The data were analyze by using fisher exact study analysis using SPSS program.
Results There were 22 patients with hypothyroid function with male proportion 63.6%. There are 2 patients
with primary hypothyroid and 20 patients with secondary hypothyroid. There is no significant correlation
between hypothyroid with hyponatremia, hypokalemia and hypocalsemia with p > 0,05. Conclusion In this
pilot study, there was no significant correlation between electrolyte imbalance with hypothyroid function.
Keywords: imbalance, electrolyte, hypothyroid

P-ENDO-004
Calcium Serum Profiles in Pediatric Patients
with Congenital Adrenal Hyperplasia Receiving Glucocorticoid Hormone
Replacement Therapy Related to Anthropometric Status

Khairiyah Amalia, Harjoedi Adji Tjahjono, Irfan Agus Salim, Fadilah Mutaqin
Department of Child Health, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital,
Malang, East Java, Indonesia

Abstract
Background Congenital adrenal hyperplasia (CAH) requires long-term glucocorticoid therapy. Decreased
of serum calcium can be a parameter of side effects using > 6 months glucocorticoid therapy in patient with
short stature. Objective To discribe the effects of glucocorticoid therapy on calcium serum levels associated
with anthropometric status. Methods This study used a cross sectional design with consecutive sampling.
Twenty pediatric patients with CAH were evaluated at the pediatric endocrinology outpatient clinic Saiful
Anwar General Hospital Malang in June 2021 who had received oral glucocorticoid 10-15 mg/m2/ day for
3-6 months. The patients were measured for weight and height, and plotted using an age-appropriate growth
curve. Serum calcium level was analyzed by electrolyte analyzer with selective ion electrode method. The data
obtained were processed and analyzed using the method Receiver Operating Characteristic (ROC) to obtain
the area under curve (AUC) value of the tool being tested. Results Respondents in this study were pediatric
patients with CAH who were given 3-6 months glucocorticoid therapy, which was known to be male (55%),
with a mean age of 2.65 years. A total of 16 respondents have short stature, with undernourished status (3
people), good nutrition (8 people) and overweight (5 people). After being given glucocorticoid therapy, it was
found that respondents who were undernourished and short in stature had the average calcium (9.3 mmol/L
± 0.98), followed by overweight and short stature (8.74 mmol/L ± 1.32). Conclusion Administration of oral
glucocorticoid 10-15 mg/m /day for 3-6 month has indirect side effects on anthropometric status in patients
2
with CAH. Most of the samples have short stature and among them are at risk of overweight. There was no
significant relationship to serum calcium levels in the incidence of short stature in this study.
Keywords: calcium serum profile; anthropometric status in CAH patient; duration of treatment

130 KONIKA XVIII Abstract Book