Page 177 - Abstract Book KONIKA 18

Endocrinology

P-ENDO-001 (Prime e-Poster)
Cardiovascular Risk Factor Profiles in Children with Type 1 Diabetes:
A Systematic Review

Naili Nur Sa’adah Nuhriawangsa1, Medita Prasetyo2
1
Faculty of Medicine and Departement of Child Health , Faculty of Medicine, Universitas Sebelas Maret/
2
Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia
Abstract
Background Type 1 DM is the most common type of DM to affect children, in which B cell destruction
usuallcaused by an autoimmune process. Cardiovascular disease is a major complication of type 1 DM. Which
the main cause of mortality and morbidity, recognized risk factors are crucial to reducing cardiovascular risk.
Objective To review cardiovascular risk factor in children with type-1 diabetes. Methods We conducted an
overall search of 4 databases from June 2 to July 27, 2021, accepting PRISMA guidelines to assess each
study using the Critical Capability Assessment Program (CASP) from the Qualitative Research Assessment
List. Results We found 8 studies that met the inclusion criteria from a total of 2.074 samples. Two results of
study stated diabetes duration, BMI, lipid-to-carbohydrate intake, and elevated lipid profile were associated
with CVD incidence. While other studies showed urinary albumin-to-creatinine ratios (ACR), recent albumin
excretion rate (AER), updated mean TG, baseline hypertension, most recent HbA1c were other risk factors.
Diabetes duration, most recent AER, baseline systolic blood pressure, baseline smoking, updated mean
HbA1c associated with major atherosclerotic cardiovascular events. Whole fruit intake related to lower DBP.
Conclusion Diabetes duration, BMI, lipid-to-carbohydrate intake, and elevated lipid are present a greater
risk for CVD in children with type-1 diabetes. While repetitive ACR, AER, updated mean TG, baseline
hypertension, most recent HbA1c should be considered as a risk factor for EIB. Whole fruit intake might be
one of the protective factors of CVD incidence.
Keywords: cardiovascular, risk factor, type 1 diabetes, child

P-ENDO-002
Subclinical Congenital Hypothyroidism with Recurrent Jaundice and Anemia:
A Case Report

Cynthia Mahardika, Wayan Bikin Suryawan
Department of Child Health, Wangaya General Hospital, Denpasar, Bali, Indonesia

Abstract
Background Congenital hypothyroidism is a clinical syndrome due to thyroid hormone deficiency that can
cause dysmorphic stature, growth disorders, and developmental disorders. It is known that 95% of congenital
hypothyroidism does not show typical clinical signs and symptoms at birth. Objective To find out the clinical
signs and symptoms that appear in newborns with congenital hypothyroidism. Case The baby girl at 37
weeks gestation was born in a sectio caesarea with birth weight: 2615 grams, birth length: 50 cm, APGAR
score: 7-8. Babies born to mothers with a history of being infected with Covid-19 at 28 weeks of gestation.
Three hours after birth the baby was moaning, breathing fast, chest wall retraction and cyanosis, so CPAP
was placed. At the age of three days, the baby appeared jaundiced (kramer 4). The baby was anemic with
Hb: 10.7 g/dL so a PRC transfusion was performed. The baby looks weak, the ability to suckle is weak and
cries are hoarse. At the age of 12 days, the baby again appeared jaundice (kramer 5), cutis marmorata all
over the body, pale skin, distention, constipation. Result of total bilirubin: 18.80 mg/dL, direct bilirubin:
0.2 mg/dL, indirect bilirubin: 18.60 mg/dL. The baby’s face looks dysmorphic, the posterior fontanel is
widened, cutis marmorata is whole body. TSH result: 6.49 Uiu/mL and FT4: 1.4 ng/dL. The patient was
given levothyroxine 1x15mcg. Conclusion Subclinical congenital hypothyroid patients with obvious clinical
symptoms and slightly elevated TSH results were given levothyroxine therapy.
Keywords: congenital hypothyroidism; anemia; jaundice; TSH; FT4

KONIKA XVIII Abstract Book 129