Page 108 - Abstract Book KONIKA 18

Allergy Immunology

P-AI-011 (Prime e-Poster)
Measles Seroprevalens and Its Related Factors in HIV Children
at Dr. Cipto Mangunkusumo Hospital, Jakarta

Mahrani Lubis , Nia Kurniati , Bernie E. Medise 2
2
1,2
1
1Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera and
2
Universitas Indonesia, Jakarta , Indonesia
Abstract
Background HIV children living in endemic measles areas must have protective measles antibodies because
they have a higher risk to be infected and get complications. There are no reports of measles antibody
seroprevalence in HIV children in Jakarta. Objective To determine the seroprevalens of measles antibodies
and its related factors in HIV children.Methods A cross-sectional study was conducted at the RSCM Allergy-
Immunology Clinic from December 2019 to February 2020. Inclusion criteria were children aged 1-18 years
who had been diagnosed with HIV and were willing to participate in this study. Blood samples were examined
to determine the value of anti-measles IgG. Seroprotective means IgG anti-measles titre ≥330 IU/l. Data
was analyzed using logistic regression test. Results Of 74 samples, there were 44 boys (59.5%), 64.9% of
children were diagnosed with HIV and received ART at 12 to 60 months, 73% of children received their first
measles vaccine before 12 months of age, 52.7% got their last measles vaccine at school age, and 55.4%
got measles vaccinations twice or more. The majority of patients without immunodeficiency (86.5%), and
50% of the sample had seroprotective status for measles antibodies. There was no significant relationship
between seroprotective status of measles antibody with age, age of first measles vaccination, frequency of
measles vaccination, and immunodeficiency status.Conclusion As 50% HIV children have seroprotective
measles antibody. There is no significant relationship between seroprotective status and age, age at first
measles vaccination, number of measles vaccination, and immunodeficiency status.
Keywords: measles; HIV; seroprotective antibody

P-AI-012
Horizontally Transmitted HIV Children in
Cipto Mangunkusumo National General Hospital: A Case Series

Melati Padma Adiprameswari, Dina Muktiarti, Nia Kurniati, Rizqi Amalia
Department of Child Health, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National General
Hospital, Jakarta, Indonesia

Abstract
Background Majority (> 90%) of HIV infection in children caused by vertical transmission from mother to
child. However, trend of HIV infection acquired by horizontal transmission in adolescent is increasing in
Indonesia. Objective To report cases of HIV infection in children acquired from horizontal transmission in
Cipto Mangunkusumo National General Hospital in 2018-2021. Cases First case is a 17-year-old boy whom
HIV diagnosed was made after treatment for genital warts. He had several anal intercourses with men. At
the time of diagnosis, his CD4 count was 239 cell/ul. He receives antiretroviral therapy (ART) consisted of
tenofovir, emtricitabine, efavirenz. His viral load was undetected after 9 months treatment. Second case is
a 16-year-old boy who had gonococcal ocular infection and cytomegalovirus infection. He also had history
of anal intercourses with his senior at school. At the time of diagnosis, his CD4 count was 215 cells/ul. He
receives tenofovir, lamivudine, efavirenz (TLE) regimen. Third case is a 16-year-old boy, who had HIV
infection from blood transfusion. He was diagnosed with beta thalassemia major and received transfusion
for 11 years. Prior to diagnosis he had tuberculosis lymphadenopathy and severe malnutrition. His mother
was HIV negative. His HIV RNA was 353.000 copies/ml and CD4 count was 11 cells/ul. He treated with
TLE regimen. His viral load was undetected after one year ART initiation. All patients already know their
HIV status and have good adherence to ART. Conclusion Healthcare providers need to consider HIV as a
differential diagnosis in adolescents with opportunistic infections.
Keywords: HIV; children; horizontal transmission

60 KONIKA XVIII Abstract Book