Page 79 - Proceeding of Plenary Abstract of Parallel Symposim

Parameter Hematologic as a Diagnosis and Prognosis in Covid-19

Wulandewi Marhaeni
Department of Child Health, Faculty of Medicine, Universitas Lambung Mangkurat/Ulin General Hospital, Banjarmasin, South Borneo, Indonesia

Abstract
Background On September 14, 2021, the total cumulative number of Covid-19 cases in Indonesia
was 4,174,216 cases and 139,415 deaths. So far, data In Indonesia suggests that children under the age
of 18 years represent about 12.8% of reported cases. To date, most children with SARS-CoV-2 infection
have been asymptomatic or had mild Covid-19 symptoms, but some children have had severe illnesses.
Timely identification of virus carriers is vital not only to prevent their spread but also to more efficiently
control disease progression. A diverse of abnormal laboratory parameters including hematological,
inflammatory as well as immunological markers thought to be raised throughout the Covid-19 outbreak.
Objective To determine the hematological parameters in the diagnosis and prognosis of Covid-19 patients.
Results Hematological parameters directly reflect the damage of SARS-CoV-2 to human blood cells, which
can better assess the severity and prognosis of patients infected with Covid-19. The main routine tests for
Covid-19 patients include complete blood count (CBC), assays investigating coagulation and fibrinolysis
cascades (PT, APTT, and D-dimers), and inflammation-related parameters (ESR, CRP, ferritin, and
procalcitonin). Hemocytopenia was common, including lymphopenia, leukopenia, and thrombocytopenia,
anemia, and increase the neutrophil-to-lymphocyte ratio (NLR), The incidence of lymphopenia in children is
not as much as in adults. The coagulation profile revealed an obvious elevation of fibrinogen, D-dimer, level
of prothrombin time (PT), and partial thromboplastin time (APTT). The inflammation-related parameters
are highly elevated in acute phases. In some Covid-19 patients thrombocytopenia and increased PT together
with prolonged APTT and elevated D-dimers further support the occurrence of coagulopathy that is common
in severe patients. Conclusion In Covid- 19 hemocytopenia was common, the occurrence of coagulopathy
is related to disease progression.

Keywords: Covid-19, hematologic parameter, coagulopathy, Neutrophil-to-lymphocyte ratio

64 Abstract