Page 275 - Abstract Book KONIKA 18

Infection & Tropical Disease

P-ITD-039
Atypical Optic Neuritis and Neuromyelitis Optica Spectrum Disorder
of Coronavirus Disease 2019 in Children: A Case Report

Ria Subekti, Nina Dwi Putri
Department of Child Health Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital,
Jakarta, Indonesia

Abstract
Background Neuro-ophthalmological manifestation of coronavirus disease 2019 (COVID-19) is a rare
condition that often misdiagnosed. Bilateral sudden vision loss is a hallmark of atypical optic neuritis and
neuromyelitis spectrum disorders related with COVID-19. Objective To demonstrate neuro-ophthalmological
manifestation related with COVID-19 and its response to systemic corticosteroid administration. Case A boy,
14 years old, came to Emergency Department of Cipto Mangunkusumo General Hospital with worsening
bilateral acute vision loss for 12 hours prior to admission. The neuro-ophthalmological manifestation started
from 10 days prior to admission, when he had first episode of tonic seizure without fever. He got bilateral
blurry vision which was worsening day by day without any history of refractory problem or ocular trauma. He
had no seizure and no focal neurological deficit from physical examination, and no focal pathological lesion
from brain contrast scanning. Laboratory examination for uveitis was within normal limit, but polymerase
chain reaction (PCR) examination of SARS-COV 2 was positive with Cq 34.00. From ophthalmological
examination there were bilateral low visual acuity (right visual acuity 2/60, left visual acuity only light
perception), papilloedema with blurry cup/disc ratio, and normal intraocular pressure. He was treated with
high dose of corticosteroid for 3 consecutive days, high dose of vitamin D, vitamin C, and valproic acid.
After 3 days of administration, the visual acuity was getting better and he was discharged from hospital to
have self-isolation. Conclusion During pandemic situation, sudden bilateral vision loss could be considered
as manifestation of COVID-19 in patients without any history of refractory problem or ocular trauma. It may
be reversible due to administration of high dose of corticosteroid as anti-inflammatory agent.
Keywords: atypical optic neuritis; neuromyelitis optic spectrum disorder; COVID-19; SARS-COV2

P-ITD-040
Bacterial Pattern and Antibiotics Resistance Pattern among Patients
in Neonatal Intensive Care Unit at Dr. M. Djamil Hospital

Rinang Mariko
Department of Child Health, Faculty of Medicine, Universitas Andalas/Dr. M. Djamil Hospital,
Padang, West Sumatera, Indonesia
Abstract
Background Bacterial culture is gold standard for diagnosing cause of neonatal sepsis, but the time lag
to obtain the result could be a problem. Therefore, empirical antibiotics can be used for the management
of neonatal sepsis while waiting for the cultures result to be completed. Having the data of bacterial
patterns, sensitivity, and antibiotics resistance is essential as guidelines for empirical antibiotics selection.
Objective We describe the bacterial and antibiotic pattern in NICU at DR M Djamil hospital.
Methods This research was conducted using a descriptive-retrospective design. Data obtained from
Microbiology Laboratory of Dr. M. Djamil Padang Hospital and medical records of NICU patients. Bacterial
culture and sensitivity test from January 2020-December 2020 were collected. Results From this study,
106 samples were obtained. Blood samples were the most common type of sample (59.4%). Most common
gram-negative bacteria found was Klebsiella pneumonia (24.6%). Most gram-positive bacteria found was
Staphylococcus epidermidis (13,3%). Most sensitive antibiotic for gram-negative bacteria was amikacin
(19.8%) and for gram-positive bacteria was vancomycin (19.7%). For the pattern of antibiotics resistance,
gram-negative bacteria were most resistant to ceftriaxone (13.5%) while gram-positive bacteria were most
resistant to ciprofloxacin and erythromycin (24.4%). Conclusion The most common gram-negative bacteria
found was Klebsiella pneumonia and most gram-positive bacteria found was Staphylococcus epidermidis.
Most sensitive antibiotic for gram-negative bacteria was amikacin and for gram-positive bacteria was
vancomycin.
Keywords: bacterial culture, antibiotic resistance, NICU

KONIKA XVIII Abstract Book 227