Page 223 - Abstract Book KONIKA 18

Gastroenterohepatology

P-GEH-026
Risk Factors Associated with Helicobacter pylori Infection
in Children with Gastrointestinal Symptoms

1
1
1
Million Polfan , Supriatmo , Winra Pratita , Gontar Alamsyah Siregar 2
1
2
Department of Child Health and Department of Internal Medicine , Faculty of Medicine, Universitas Sumatera Utara,
Medan, North Sumatera, Indonesia
Abstract
Background Main etiology of peptic ulcer disease in children is H. pylori, which has also been proven as a
carcinogen in human. With an estimated high prevalence and its chronic nature, it is important to determine
the risk factors for H. pylori infection. Studies in adults have shown association of H. pylori infection with
several risk factors, but research in children is still scarce. Objective To determine the risk factors associated
with H. pylori infection in children with gastrointestinal symptoms. Methods A case control study in children
with gastrointestinal symptoms treated at H. Adam Malik General Hospital in Medan from September 2019
- June 2020. Diagnosis of H. pylori infection was made if one of the diagnostic tests was positive. Data was
then collected from parents with a questionnaire guidance and was analysed to determine the association
between the risk factors with the incidence of H. pylori infection. Results A total of 68 children (34 cases
and 34 controls) met the criteria as sample. Age range of subjects was between 2-17 years with a median
of 12.5 years. Routine hand washing (before eating, after defecation, and when hands were dirty) decreases
the risk of H. pylori infection (OR 0.2; 95%CI 0.4 to 1.04; P=0.040). History of bottle feeding beyond 2
years old increases the risk of H. pylori infection (OR 3.59; 95%CI 1.01 to 12.73; P=0.041). Conclusion
Routine hand washing and a history of bottle feeding beyond 2 years old are associated with the incidence
of H. pylori infection.
Keywords: Helicobacter pylori; risk factors; children; gastrointestinal

P-GEH-027
Correlation between Absolute Neutrophil Count Level
and Helicobacter pylori Infection in Pediatric Gastritis

Hotasi Otana Simanjuntak, Supriatmo, Aridamuriany Dwiputri Lubis
Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia

Abstract
Background Helicobacter pylori infection is the most common cause of gastritis worldwide and associated
with gastric ulcer and cancer. There are not many studies assessing the significance of baseline and clinical
characteristics, and absolute neutrophil count (ANC) in H. pylori associated gastritis. Objective To assess
the correlation of baseline and clinical characteristics and ANC with pediatric H. pylori associated gastritis.
Methods This was analytical cross-sectional research to pediatric patients with gastritis in Haji Adam Malik
and Universitas Sumatera Utara hospitals between October - December 2020. H. pylori screening and ANC
test were conducted. Independent t-test and Mann-Whitney test were used to assess the correlation. Results
From 82 research subjects, 45 subjects were positive H. pylori and 37 subjects were negative. Demographic
data, such as age, gender, ethnicity, socioeconomic status, level of education of children and parents, and
parents’ occupation, was not significantly correlated to H. pylori infection. Clinical data, such as body height
and weight, nutritional status, and symptoms, was not significantly correlated to H. pylori infection. There was
no significant difference between ANC and H. pylori infection in the two groups. Conclusion There were no
significant differences in baseline and clinical characteristic data and ANC with pediatric H. pylori gastritis.
Keywords: absolute neutrophil count; Helicobacter pylori; children

KONIKA XVIII Abstract Book 175