Page 191 - Abstract Book KONIKA 18

Endocrinology

P-ENDO-029
Correlation between Androsteron, Etiocholanolone Urine with
17-Hydroxyprogesterone in Congenital Adrenal Hyperplasia due to
21-Hydroxylase Deficiency in Treatment Monitoring

Bina Akura , Partini Pudjiastuti Trihono , Bambang Tridjaja , Andi Nanis Sacharina Marzuki ,
1
2
1
1
3
1
Adhi Teguh Perma Iskandar , Muhammad Faizi , Frida Soesanti 1
Department of Child Health, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta 1
3
and Universitas Airlangga, Surabaya, East Java , Eijkman Institute for Molecular Biology, Jakarta , Indonesia
2
Abstract
Background Congenital adrenal hyperplasia (CAH) is a disorder characterized by defects in one of the
enzymes of the adrenal steroidogenesis pathway. Treatment monitoring in CAH patients is quite difficult
to achieve, due to fine balance of overtreatment and undertreatment. Objective To compare the level
of 17-hydroxyprogesterone (17-OHP), urine androsterone, etiocholanolone, and ratio androsterone/
etiocholanolone (A/E) in CAH with control group. Methods this was a cross sectional study, from June to
December 2020, in RSCM for 7 months. There were 71 patients CAH included in this study. Controls were
selected by matching age and sex. In CAH group, 17-hydroxyprogesterone (17-OHP), urine androsterone,
etiocholanolone, and ratio androsterone/etiocholanolone (A/E) were measured. Correlations were measured
between those variables. In control sample urine androsterone, etiocholanolone, and ratio A/E were also
measured. These results were compared between two groups. Results Both groups had similar characteristics.
Androsterone level in CAH group was significantly higher, (683.89 (29.42-61061.43) vs. 123.97 (30.16-
16463.05) ng/mL, P<0.001, respectively). Etiocholanolone level in CAH group was also significantly higher
(235.88 vs. 70.96 ng/mL; P<0.001, respectively). Ratio A/E was significantly different between CAH and
control (2.31 vs. 1.99; P=0.003, respectively). Androsterone, etiocholanolone and ratio A/E had positive
correlation with 17-OHP level (r=0.5050; r=0.367; r=0.313, respectively). Conclusions Androsterone,
etiocholanolone, and ratio A/E were significantly higher in CAH than control group. Androsterone had
moderate correlation with 17-OHP, meanwhile etiocholanolone and ratio A/E had weaker correlation.
Funding Acknowledgment. The authors would like to thank Universitas Indonesia for funding this research
through PUTI Grant with contract number NKB-2199/UN2.RST/HKP.05.00/2020
Keywords: androsterone; CAH; etiocholanolone; ratio A/E

P-ENDO-030
Comparison of Thyrotropin Receptor Antibodies Levels Before and After
Methimazole Therapy for 6 Months in Children with Graves Disease
in H. Adam Malik Hospital
Satrio Bhuwono Prakoso, Karina Sugih Arto, Lily Irsa, Melda Deliana, Siska Mayasari Lubis
Child Health Departement, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Abstract
Background Graves disease is the leading cause of hyperthyroidisme in children. Methimazole (MMI) is
the main therapy for hyperthyroidisme in children, it may give good response to patients with new-onset
Graves disease, high levels of thyroxine, high Thyrotropin Receptor Antibody (TRAb), and nor small goiters
Objective To determine the differences in fT4 (free Thyroxine), TSH (Thyroid Stimulating Hormone),
TRAb levels before and after Methimazole therapy for 6 months in children with Graves disease.
Methods Retrospective study on 28 children with Graves disease at H. Adam Malik General Hospital
Medan from March 2018-March 2021. This Study collected TRAb, fT4, TSH levels data before and after
Methimazole therapy for 6 months taken from medical records. Patients with incomplete data were excluded.
Results Median age 11.85 ± 3.73 with the number of girls 85.7% compared to boys 14.3%. The median value
before Methimazole therapy was TRAb 32.11 IU/L, fT4 3.56 ng/dL and TSH 0.01 mU/L. Median values after
6 months of Methimazole therapy were TRAb 17.15 IU/L, fT4 1.51 ng/dL and TSH 0.51 mU/l (P<0.001,
0.006, 0.001 respectively). Conclusion There were significant differences in TRAb, fT4, and TSH median
values before and after 6 months of Methimazole therapy in children with Graves disease.
Keywords: hyperthyroidism; Graves disease; TRAb; fT4; methimazole

KONIKA XVIII Abstract Book 143